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Type: Artigo de periódico
Title: Hemodynamic Effects Of Local Anesthetics Intoxication: Experimental Study In Swine With Levobupivacaine And Bupivacaine.
Author: Udelsmann, Artur
Lorena, Sílvia Elaine Rodolfo de Sá
Girioli, Samira Ubaid
Silva, William Adalberto
Moraes, Ana Cristina de
Andreollo, Nelson Adami
Abstract: To compare the hemodynamic repercussions following a toxic dose of levobupivacaine and bupivacaine intravascularly injected in swines. Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization (Swan-Ganz catheter). After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus injection of 4 mg/kg of either agent for intoxication. Hemodynamic results were then evaluated at 1, 5, 10, 15, 20 and 30 minutes. Levobupivacaine had greater hemodynamic repercussions than racemic bupivacaine. These results disagree with those found when the levorotatory isomer of bupivacaine was used in humans, but are in agreement with recently reported findings in animals. Levobupivacaine was shown to be more toxic in pigs than racemic bupivacaine when large doses are injected intravenously.
Subject: Anesthetics, Local
Cardiovascular System
Central Venous Pressure
Disease Models, Animal
Drug Evaluation, Preclinical
Heart Diseases
Random Allocation
Vascular Resistance
Citation: Acta Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 23, n. 1, p. 55-64
Rights: aberto
Appears in Collections:Unicamp - Artigos e Outros Documentos

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