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Type: Artigo de periódico
Title: Polymorphisms Of Methylenetetrahydrofolate Reductase (mthfr), Methionine Synthase (mtr), Methionine Synthase Reductase (mtrr), And Thymidylate Synthase (tyms) In Multiple Myeloma Risk.
Author: Lima, Carmen S P
Ortega, Manoela M
Ozelo, Margareth C
Araujo, Renato C
De Souza, Cármino A
Lorand-Metze, Irene
Annichino-Bizzacchi, Joyce M
Costa, Fernando F
Abstract: We tested whether the polymorphisms of the methylenetetrahydrofolate reductase gene, MTHFR C677T and A1298C, the methionine synthase gene, MTR A2756G, the methionine synthase reductase gene, MTRR A66G, and the thymidylate synthase gene, TYMS 2R-->3R, involved in folate and methionine metabolism, altered the risk for multiple myeloma (MM). Genomic DNA from 123MM patients and 188 controls was analysed by polymerase chain reaction and restriction digestion for the polymorphism analyses. The frequency of the MTR 2756 AG plus GG genotype was higher in patients than in controls (39.8% versus 23.4%, P=0.001). Individual carriers of the variant allele G had a 2.31 (95% CI: 1.38-3.87)-fold increased risk for MM compared with others. In contrast, similar frequencies of the MTHFR, the MTRR and the TYMS genotypes were seen in patients and controls. These results suggest, for the first time, a role for the MTR A2756G polymorphism in MM risk in our country, but should be confirmed by large-scale epidemiological studies with patients and controls age matched.
Subject: 5-methyltetrahydrofolate-homocysteine S-methyltransferase
Ferredoxin-nadp Reductase
Gene Frequency
Genetic Predisposition To Disease
Methylenetetrahydrofolate Reductase (nadph2)
Middle Aged
Multiple Myeloma
Polymorphism, Genetic
Risk Factors
Thymidylate Synthase
Citation: Leukemia Research. v. 32, n. 3, p. 401-5, 2008-Mar.
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2007.06.001
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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