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Type: Artigo de periódico
Title: Assessment Of Neurosurgical Outcome In Children Prenatally Diagnosed With Myelomeningocele And Development Of A Protocol For Fetal Surgery To Prevent Hydrocephalus.
Author: Zambelli, Helder
Carelli, Edmur
Honorato, Donizeti
Marba, Sérgio
Coelho, Giselle
Carnevalle, Aline
Iscaife, Alexandre
da Silva, Elton
Barini, Ricardo
Sbragia, Lourenço
Abstract: Prenatal diagnosis of myelomeningocele (MMC) has permitted a better planning for optimum management of the disease. More recently, it has allowed for a possible intrauterine repair of the spinal defect. To describe neurosurgical outcome in children with myelomeningocele and follow-up at a referral center in Fetal Medicine. Patients were characterized for the development of a protocol suitable for fetal surgery, and fetuses who were possible candidates for intrauterine surgery were identified. A retrospective descriptive analysis was performed of 98 cases of fetal myelomeningocele, seen at CAISM-UNICAMP, from January 1994 to December 2002, identifying cases with a possible indication for fetal surgery. Mean gestational age at diagnosis was 29 weeks (17-39); level of lesion was above the sacral region in 92.84%; association with hydrocephalus occurred in 78.57%. During clinical course, 82.5% of patients had neurogenic bladder and 60% had neural and mental deficits. Potential intrauterine repair rate was 11.57%, using criteria from the protocol developed in our service. Myelomeningocele is associated with severe and frequent sequelae. In virtually 12% of our cases, fetal surgery could have been offered as a therapeutic option.
Subject: Adult
Fetal Diseases
Follow-up Studies
Retrospective Studies
Treatment Outcome
Citation: Child's Nervous System : Chns : Official Journal Of The International Society For Pediatric Neurosurgery. v. 23, n. 4, p. 421-5, 2007-Apr.
Rights: fechado
Identifier DOI: 10.1007/s00381-006-0261-x
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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