Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: A Possible Anti-proliferative And Anti-metastatic Effect Of Irradiated Riboflavin In Solid Tumours.
Author: de Souza Queiroz, Karla Cristiana
Zambuzzi, Willian Fernando
Santos de Souza, Ana Carolina
da Silva, Rodrigo Augusto
Machado, Daisy
Justo, Giselle Zenker
Carvalho, Hernandes F
Peppelenbosch, Maikel P
Ferreira, Carmen Veríssima
Abstract: Riboflavin is a potent photosensitizer as well as part of the vitamin B complex. Recently we demonstrated that the products generated by irradiation of riboflavin have potential as anti-leukaemic therapy. The possible action, however, of the riboflavin photoproducts in solid cancers has not been addressed. Hence, we investigated the effects of irradiated riboflavin on androgen-independent human prostate cancer cells (PC3), a known model for solid tumour cells with an exceptional resistance to therapy. Our results show that riboflavin photoproducts are cytotoxic to these cells in a FasL-Fas-dependent manner. Furthermore, irradiated riboflavin inhibited matrix-degrading proteases, caused downregulation of VEGF and upregulation of TIMP1 suggesting anti-metastatic potential. Together, these results show that the anti-neoplastic action of riboflavin photoproducts is not limited to haematological malignancies, warranting clinical studies in solid tumours.
Subject: Animals
Blotting, Western
Cell Proliferation
Cells, Cultured
Neoplasms, Hormone-dependent
Photosensitizing Agents
Prostatic Neoplasms
Citation: Cancer Letters. v. 258, n. 1, p. 126-34, 2007-Dec.
Rights: fechado
Identifier DOI: 10.1016/j.canlet.2007.08.024
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_17933458.pdf280.02 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.