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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleLeishmania Amazonensis: Multiple Receptor-ligand Interactions Are Involved In Amastigote Infection Of Human Dendritic Cells.pt_BR
dc.contributor.authorBosetto, Maira Cegattipt_BR
dc.contributor.authorGiorgio, Selmapt_BR
unicamp.authorMaira Cegatti Bosetto, Departamento de Parasitologia, Instituto de Biologia, Universidade Estadual de Campinas, Caixa Postal 6109, Cep 13083-970, Campinas, São Paulo, Brazil.pt_BR
unicamp.author.externalSelma Giorgio,pt
dc.subjectAnimalspt_BR
dc.subjectAntibodies, Protozoanpt_BR
dc.subjectCell Adhesion Moleculespt_BR
dc.subjectCells, Culturedpt_BR
dc.subjectComplement System Proteinspt_BR
dc.subjectDendritic Cellspt_BR
dc.subjectHeparitin Sulfatept_BR
dc.subjectHumanspt_BR
dc.subjectImmune Serapt_BR
dc.subjectLectins, C-typept_BR
dc.subjectLeishmania Mexicanapt_BR
dc.subjectLigandspt_BR
dc.subjectMannanspt_BR
dc.subjectMannose-binding Lectinspt_BR
dc.subjectMicept_BR
dc.subjectMice, Inbred C3hpt_BR
dc.subjectMice, Nudept_BR
dc.subjectOpsonin Proteinspt_BR
dc.subjectProteoglycanspt_BR
dc.subjectReceptors, Cell Surfacept_BR
dc.subjectReceptors, Complementpt_BR
dc.subjectReceptors, Fcpt_BR
dc.description.abstractIn their mammalian hosts, Leishmania are obligate intracellular parasites that reside in macrophages and dendritic cells (DCs). In the present study, we have investigated in vitro the mechanisms of entry into human DCs of Leishmania amazonensis amastigotes isolated from lesions in nude mice (Am nude). The DC infection rate with Am nude was approximately 36%, while opsonization of Am nude with normal human serum and infected human serum increased the DC infection rates to 60% and 62%, respectively. Heat inactivation and depletion of antibodies in sera brought the DC infection rate down to 40%. The DC infection rate was inhibited after pre-treatment of Am nude with heparin. We were unable to implicate mannose-fucose receptors in the uptake of Am nude by DCs. Our data suggest that the ability of L. amazonensis amastigotes to infect human DCs involves the participation of at least three multiple receptor-ligand interactions, antibodies/FcR, complement components/CR and proteoglycans/heparin-binding protein.en
dc.relation.ispartofExperimental Parasitologypt_BR
dc.relation.ispartofabbreviationExp. Parasitol.pt_BR
dc.date.issued2007-Julpt_BR
dc.identifier.citationExperimental Parasitology. v. 116, n. 3, p. 306-10, 2007-Jul.pt_BR
dc.language.isoengpt_BR
dc.description.volume116pt_BR
dc.description.firstpage306-10pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0014-4894pt_BR
dc.identifier.doi10.1016/j.exppara.2007.01.003pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/17320869pt_BR
dc.date.available2015-11-27T13:09:49Z-
dc.date.accessioned2015-11-27T13:09:49Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:09:49Z (GMT). No. of bitstreams: 1 pmed_17320869.pdf: 234358 bytes, checksum: fcd389d12fd6251af8d15753cae49b9c (MD5) Previous issue date: 2007en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197182-
dc.identifier.idPubmed17320869pt_BR
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