Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197127
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleThe Putative Telomerase Reverse Transcriptase Component Of Leishmania Amazonensis: Gene Cloning And Characterization.pt_BR
dc.contributor.authorGiardini, Miriam Apt_BR
dc.contributor.authorLira, Cristina B Bpt_BR
dc.contributor.authorConte, Fábio Fpt_BR
dc.contributor.authorCamillo, Luciana Rpt_BR
dc.contributor.authorde Siqueira Neto, Jair Lpt_BR
dc.contributor.authorRamos, Carlos H Ipt_BR
dc.contributor.authorCano, Maria Isabel Npt_BR
unicamp.authorMiriam A Giardini, Departamento de Patologia Clínica, Núcleo de Medicina e Cirurgia Experimental, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), CP 6109, Campinas, SP, CEP 13083-970, Brazil.pt_BR
unicamp.author.externalCristina B B Lira,pt
unicamp.author.externalFábio F Conte,pt
unicamp.author.externalLuciana R Camillo,pt
unicamp.author.externalJair L de Siqueira Neto,pt
unicamp.author.externalCarlos H I Ramos,pt
unicamp.author.externalMaria Isabel N Cano,pt
dc.subjectAmino Acid Sequencept_BR
dc.subjectAnimalspt_BR
dc.subjectChromosome Mappingpt_BR
dc.subjectChromosomespt_BR
dc.subjectCloning, Molecularpt_BR
dc.subjectDna Primerspt_BR
dc.subjectDna, Protozoanpt_BR
dc.subjectEvolution, Molecularpt_BR
dc.subjectLeishmania Majorpt_BR
dc.subjectLeishmania Mexicanapt_BR
dc.subjectMolecular Sequence Datapt_BR
dc.subjectPhylogenypt_BR
dc.subjectPolymerase Chain Reactionpt_BR
dc.subjectRna, Messengerpt_BR
dc.subjectSequence Alignmentpt_BR
dc.subjectSequence Analysis, Dnapt_BR
dc.subjectSequence Homology, Amino Acidpt_BR
dc.subjectTelomerasept_BR
dc.description.abstractThe Leishmania amazonensis telomerase gene was cloned by a polymerase chain reaction-based strategy using primers designed from a Leishmania major sequence that shared similarities with conserved telomerase motifs. The genes from three other species were cloned for comparative purposes. A ClustalW multiple-sequence alignment demonstrated that the Leishmania telomerases show greater homology with each other than with the proteins of other kinetoplastids and eukaryotes. Characterization experiments indicated that the putative Leishmania telomerase gene was probably in single copy and located in the largest chromosomes. A single messenger ribonucleic acid transcript was found in promastigotes. Phylogenetic analysis suggested that Leishmania telomerase might represent a liaison between the oldest and the newest branches of telomerases.en
dc.relation.ispartofParasitology Researchpt_BR
dc.relation.ispartofabbreviationParasitol. Res.pt_BR
dc.date.issued2006-Aprpt_BR
dc.identifier.citationParasitology Research. v. 98, n. 5, p. 447-54, 2006-Apr.pt_BR
dc.language.isoengpt_BR
dc.description.volume98pt_BR
dc.description.firstpage447-54pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0932-0113pt_BR
dc.identifier.doi10.1007/s00436-005-0036-4pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16416120pt_BR
dc.date.available2015-11-27T13:06:15Z-
dc.date.accessioned2015-11-27T13:06:15Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:06:15Z (GMT). No. of bitstreams: 1 pmed_16416120.pdf: 479324 bytes, checksum: ea929a2bcc780cd913930b06537184c3 (MD5) Previous issue date: 2006en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197127-
dc.identifier.idPubmed16416120pt_BR
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