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Type: Artigo de periódico
Title: Prophylactic Administration Of Withania Somnifera Extract Increases Host Resistance In Listeria Monocytogenes Infected Mice.
Author: Teixeira, Silvia T
Valadares, Marize C
Gonçalves, Shirley A
de Melo, Adriana
Queiroz, Mary L S
Abstract: In this study, we demonstrated that Withania somnifera L. extract (WSE) protects mice from a lethal dose of Listeria monocytogenes when administered prophylactically at 100, 250 and 500 mg/kg for 10 days, with survival rates up to 30%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with L. monocytogenes, due to increased numbers of granulocyte-macrophage progenitors (CFU-GM) in the bone marrow. Investigation of the production of colony-stimulating factors (CSFs) revealed increased colony-stimulating activity (CSA) in the serum of normal and infected mice pre-treated with WSE. Further studies to investigate the levels of interferon-gamma (INF-gamma) and lymphocyte cell proliferation were undertaken. We observed dose-dependent increases in cell proliferation and in the levels of INF-gamma in mice infected with L. monocytogenes and treated with WSE. All together, our results suggest that WSE indirectly modulates immune activity and probably disengages Listeria-induced suppression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow, proliferation of lymphocytes and increased INF-gamma levels.
Subject: Animals
Cell Proliferation
Disease Models, Animal
Granulocyte-macrophage Colony-stimulating Factor
Listeria Monocytogenes
Mice, Inbred Balb C
Plant Extracts
Citation: International Immunopharmacology. v. 6, n. 10, p. 1535-42, 2006-Oct.
Rights: fechado
Identifier DOI: 10.1016/j.intimp.2006.03.016
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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