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Type: Artigo de periódico
Title: Inducible-nos But Not Neuronal-nos Participate In The Acute Effect Of Tnf-alpha On Hypothalamic Insulin-dependent Inhibition Of Food Intake.
Author: Moraes, Juliana C
Amaral, Maria E
Picardi, Paty K
Calegari, Vivian C
Romanatto, Talita
Bermúdez-Echeverry, Marcela
Chiavegatto, Silvana
Saad, Mario J
Velloso, Licio A
Abstract: TNF-alpha acts on the hypothalamus modulating food intake and energy expenditure through mechanisms incompletely elucidated. Here, we explore the hypothesis that, to modulate insulin-induced anorexigenic signaling in hypothalamus, TNF-alpha requires the synthesis of NO. TNF-alpha activates signal transduction through JNK and p38 in hypothalamus, peaking at 10(-8) M. This is accompanied by the induction of expression of the inducible and neuronal forms of NOS, in both cases peaking at 10(-12) M. In addition, TNF-alpha stimulates NOS catalytic activity. Pre-treatment with TNF-alpha at a low dose (10(-12) M) inhibits insulin-dependent anorexigenic signaling, and this effect is abolished in iNOS but not in nNOS knockout mice.
Subject: Animals
Dose-response Relationship, Drug
Feeding Behavior
Injections, Intraventricular
Mice, Inbred C57bl
Mice, Knockout
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type Ii
Rats, Wistar
Tumor Necrosis Factor-alpha
Citation: Febs Letters. v. 580, n. 19, p. 4625-31, 2006-Aug.
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2006.07.042
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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