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Type: Artigo de periódico
Title: Comparative Analysis Of Two-dimensional Electrophoresis Maps (2-de) Of Helicobacter Pylori From Brazilian Patients With Chronic Gastritis And Duodenal Ulcer: A Preliminary Report.
Author: Pereira, Diego R B
Martins, Daniel
Winck, Flavia V
Smolka, Marcus B
Nishimura, Nancy F
Rabelo-Gonçalves, Elizabeth M A
Hara, Natalicia H
Marangoni, Sérgio
Zeitune, José Murilo R
Novello, José Camillo
Abstract: Helicobacter pylori is a bacterium recognized as the major cause of peptic ulcer and chronic gastritis. Recently, a proteome-based approach was developed to investigate pathogenic factors related to H. pylori. In this preliminary study, H. pylori strains were isolated from gastric biopsies of patients with chronic gastritis and duodenal ulcers. A partial proteomic analysis of H. pylori strains was performed by bacterial lyses and proteins were separated by two-dimensional gel electrophoresis (2-DE). A comparative analysis was performed to verify a differential protein expression between these two 2-DE maps. These data should be useful to clarify the role of different proteins related to bacterial pathogenesis. This study will be completed using a larger number of samples and protein identification of H. pylori by MALDI-TOF mass spectrometry.
Subject: Bacterial Proteins
Chronic Disease
Duodenal Ulcer
Electrophoresis, Gel, Two-dimensional
Gastric Mucosa
Helicobacter Infections
Helicobacter Pylori
Citation: Revista Do Instituto De Medicina Tropical De São Paulo. v. 48, n. 3, p. 175-7
Rights: aberto
Identifier DOI: /S0036-46652006000300011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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