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Type: Artigo de periódico
Title: Role Of Glutathione-s-transferase And Codon 72 Of P53 Genotypes In Epithelial Ovarian Cancer Patients.
Author: Morari, Elaine Cristina
Lima, Andre Bacellar Costa
Bufalo, Natassia Elena
Leite, Janaina Luisa
Granja, Fabiana
Ward, Laura Sterian
Abstract: A series of polymorphisms in germ-line DNA have been investigated in an effort to delineate polygenic models of cancer susceptibility and prognosis. As low-penetrance susceptibility genes may combine additively or multiplicatively and contribute to cancer incidence and to the response to chemotherapy, we studied GSTT1, GSTM1, GSTO2, GSTP1 and codon 72 of p53 genotype profiles in ovarian cancer patients. We compared 69 ovarian cancer patients with 222 control healthy women paired for ethnic and life-style characteristics. Outcome was evaluated in 29 stage III and IV patients submitted to a platinum-based chemotherapy followed-up for 6-29 months (17 +/- 9 months). GSTT1, GSTM1, GSTO2 and GSTP1 genes presented a similar genotype distribution, but codon 72 of p53 gene wild-type variant was less frequent in ovarian cancer patients than in controls (chi(2); P = 0.0004). We were unable to demonstrate any association between the GST genotypes studied and the risk of ovarian cancer but the inheritance of a heterozygous Arg/Pro genotype of p53 increased the risk of ovarian cancer more than 2.5 times (OR = 2.571; 95% CI = 1.453-4.550). There was no association of the studied genes to any clinical or pathological feature of the patients or to their response to chemotherapy.
Subject: Adult
Antineoplastic Combined Chemotherapy Protocols
Disease Susceptibility
Genes, P53
Glutathione S-transferase Pi
Glutathione Transferase
Life Style
Middle Aged
Neoplasm Staging
Odds Ratio
Ovarian Neoplasms
Polymorphism, Genetic
Risk Assessment
Risk Factors
Treatment Outcome
Citation: Journal Of Cancer Research And Clinical Oncology. v. 132, n. 8, p. 521-8, 2006-Aug.
Rights: fechado
Identifier DOI: 10.1007/s00432-006-0099-3
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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