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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.title[the Hypothalamic Control Of Feeding And Thermogenesis: Implications On The Development Of Obesity].pt_BR
dc.contributor.authorVelloso, Lício Apt_BR
unicamp.authorLício A Velloso, Departamento de Clínica Médica, FCM, UNICAMP, Campinas, SP. lavelloso@fcm.unicamp.brpt_BR
dc.subjectDiabetes Mellitus, Type 2pt_BR
dc.subjectEatingpt_BR
dc.subjectHumanspt_BR
dc.subjectHypothalamuspt_BR
dc.subjectInsulin Resistancept_BR
dc.subjectLeptinpt_BR
dc.subjectLife Stylept_BR
dc.subjectObesitypt_BR
dc.subjectThermogenesispt_BR
dc.subjectTranscription, Geneticpt_BR
dc.description.abstractThe worldwide increase in the prevalence of obesity is becoming one of the most important clinical-epidemiological phenomena of the present days. Environmental factors such as changes in life-style and feeding behavior associated with poorly characterized genetic determinants are though to play the most important roles in the pathogenesis of this disease. During the last ten years, since the discovery of leptin, great advances were obtained in the characterization of the hypothalamic mechanisms involved in the control of food intake and thermogenesis. Such advances are unveiling a complex and integrated system and are opening a wide perspective for the finding of novel therapeutic targets for the treatment of this harming condition. This review will present some of the most recent findings in this field. It will be focused on the actions of leptin and insulin in the hypothalamus and will explore the hypothesis that hypothalamic resistance to the action of these hormones may play a role in the development of obesity and may act as a molecular link between obesity, type 2 diabetes mellitus and other clinical conditions on which insulin resistance plays an important pathogenetic role.en
dc.relation.ispartofArquivos Brasileiros De Endocrinologia E Metabologiapt_BR
dc.relation.ispartofabbreviationArq Bras Endocrinol Metabolpt_BR
dc.date.issued2006-Aprpt_BR
dc.identifier.citationArquivos Brasileiros De Endocrinologia E Metabologia. v. 50, n. 2, p. 165-76, 2006-Apr.pt_BR
dc.language.isoporpt_BR
dc.description.volume50pt_BR
dc.description.firstpage165-76pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0004-2730pt_BR
dc.identifier.doi/S0004-27302006000200003pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16767283pt_BR
dc.date.available2015-11-27T13:05:31Z-
dc.date.accessioned2015-11-27T13:05:31Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:05:31Z (GMT). No. of bitstreams: 1 pmed_16767283.pdf: 1105614 bytes, checksum: f5651d8fa7ce64fb351cf320ae05cdf0 (MD5) Previous issue date: 2006en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196805-
dc.identifier.idPubmed16767283pt_BR
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