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Type: Artigo de periódico
Title: Prognostic Factors In Head And Neck Adenoid Cystic Carcinoma.
Author: da Cruz Perez, Danyel Elias
de Abreu Alves, Fábio
Nobuko Nishimoto, Inês
de Almeida, Oslei Paes
Kowalski, Luiz Paulo
Abstract: The aim of this study was to analyse the clinical, histological and immunohistochemical prognostic factors of a large series of adenoid cystic carcinoma, using univariate and multivariate survival analyses. All cases of head and neck ACC (n = 129) treated in a single institution in Brazil, between 1955 and 1997, were selected for the study. Univariate survival analysis revealed that age older than 45 years (p = 0.04), period of complaints inferior to 18 months (p = 0.007), presence of paresthesia (p = 0.04), T stage (p = 0.01), N stage (p = 0.04), M stage (p < 0.001), clinical stage (p = 0.003), solid histological type ( p< 0.001), presence of residual tumor (p < 0.001) and expression of p53 (p = 0.08) correlated with a poor prognosis. In the multivariate survival analyses, clinical stage, solid histological subtype and increased expression of p53 were independent significant prognostic factors. According to our findings, clinical stage, solid growth pattern and expression of p53 were the most important prognostic factors in patients with ACC.
Subject: Adolescent
Aged, 80 And Over
Carcinoma, Adenoid Cystic
Epidemiologic Methods
Head And Neck Neoplasms
Lymphatic Metastasis
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Salivary Gland Neoplasms
Treatment Outcome
Tumor Markers, Biological
Tumor Suppressor Protein P53
Citation: Oral Oncology. v. 42, n. 2, p. 139-46, 2006-Feb.
Rights: fechado
Identifier DOI: 10.1016/j.oraloncology.2005.06.024
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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