Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Antiulcerogenic Activity Of A Crude Hydroalcoholic Extract And Coumarin Isolated From Mikania Laevigata Schultz Bip.
Author: Bighetti, A E
Antônio, M A
Kohn, L K
Rehder, V L G
Foglio, M A
Possenti, A
Vilela, L
Carvalho, J E
Abstract: The leaves of Mikania (Asteraceae) species are used in folk medicine as antispasmodic, antiulcerogenic and antirheumatic agents. Phytochemical screening of the crude hydroalcoholic 70% extract (CHE) of Mikania laevigata Shultz Bip. revealed coumarins, terpenes and organic acids. Antiulcerogenic activity of CHE was evaluated, employing different experimental models in rats, to discern the pharmacological mechanism of action. Both the antisecretory and the cytoprotection hypothesis were evaluated. The crude hydroalcoholic extract (1000 mg/kg body wt., vo) decreased the ulcerative lesion index produced by indomethacin, ethanol, stress and reserpine in rats by 85%, 93%, 82% and 50%, respectively. In the pyloric ligation model, a decrease of hydrogenionic concentration (53%) was observed, suggesting that the pharmacological mechanism has a relationship to antisecretory activity. The antisecretory mechanisms of CHE and the coumarin isolated from M. laevigata were confirmed by acid hypersecretion induced by histamine, pentagastrin and bethanechol. Duodenal administration of CHE (1000 mg/kg body wt.) and coumarin (100 mg/kg body wt.) inhibited only the gastric acid secretion produced by bethanecol. These results suggest that both CHE and coumarin may influence the secretion control mediated by the parasympathetic system.
Subject: Animals
Anti-ulcer Agents
Disease Models, Animal
Dose-response Relationship, Drug
Duodenal Ulcer
Plant Extracts
Plant Leaves
Rats, Wistar
Stress, Physiological
Citation: Phytomedicine : International Journal Of Phytotherapy And Phytopharmacology. v. 12, n. 1-2, p. 72-7, 2005-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.phymed.2003.09.006
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_15693711.pdf214.87 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.