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Type: Artigo de periódico
Title: Relationship Of Age To Outcome And Clinicopathologic Findings In Men Submitted To Radical Prostatectomy.
Author: Billis, Athanase
Magna, Luis A
Lira, Mariana M
Moreira, Luciana R
Okamura, Helio
Paz, Alexandre R
Perina, Rita C
Triglia, Renata M
Ferreira, Ubirajara
Abstract: It is controversial whether age is associated with higher grade and worse outcome. Some studies have not found age to be related to outcome nor younger age to be associated with better response to therapy. The study population consisted of 27 patients aged 55 years or younger and 173 patients 56 years or older submitted to radical prostatectomy. The variables studied were preoperative PSA, time to PSA progression following radical prostatectomy and pathologic findings in surgical specimens: Gleason score, Gleason predominant grade, positive surgical margins, tumor extent, extraprostatic extension (pT3a), and seminal vesicle invasion (pT3b). Comparing patients aged 55 years or younger and 56 years or older, there was no statistically significant difference for all variables studied: preoperative PSA (p = 0.4417), Gleason score (p = 0.3934), Gleason predominant grade (p = 0.2653), tumor extent (p = 0.1190), positive surgical margins (p = 0.8335), extraprostatic extension (p = 0.3447) and seminal vesicle invasion (p > 0.9999). During the study period, 44 patients (22%) developed PSA progression. No difference was found in the time to biochemical progression between men aged 55 years or younger and 56 years or older. Our findings suggest that age alone do not influence the biological aggressiveness of prostate cancer.
Subject: Age Factors
Disease Progression
Disease-free Survival
Follow-up Studies
Middle Aged
Neoplasm Invasiveness
Prostate-specific Antigen
Prostatic Neoplasms
Seminal Vesicles
Time Factors
Treatment Outcome
Citation: International Braz J Urol : Official Journal Of The Brazilian Society Of Urology. v. 31, n. 6, p. 534-9; discussion 539-40
Rights: aberto
Appears in Collections:Unicamp - Artigos e Outros Documentos

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