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Type: Artigo de periódico
Title: Tissue Remodeling In Guinea Pig Lateral Prostate At Different Ages After Estradiol Treatment.
Author: Scarano, Wellerson Rodrigo
Cordeiro, Renato Simões
Góes, Rejane Maira
Carvalho, Hernandes F
Taboga, Sebastião Roberto
Abstract: Estrogen seems to have an essential role in the fibromuscular growth characteristic of benign prostatic hyperplasia (BPH). This paper describes the effects of chronic estradiol treatment on Guinea pig prostatic stroma at different ages. Tissues from experimental animals were studied by histological and histochemical procedures, morphometric-stereological analysis and transmission electron microscopy (TEM). Marked fibromuscular hypertrophy was observed after estradiol treatment in animals of pre-pubertal and adult ages. Increases in the density and thickness of the collagen and elastic fibers were observed by histochemistry. TEM revealed wide distributions of collagen fibrils and large elastic fibers adjacent to the epithelial basal lamina and between the stromal cells, establishing contacts between them. These results indicate that the Guinea pig prostate simulates the stromal modifications observed in BPH in some aged animals after estrogen treatment at different ages, making it a good model for this disease.
Subject: Age Factors
Disease Models, Animal
Epithelial Cells
Guinea Pigs
Microscopy, Electron, Transmission
Myocytes, Smooth Muscle
Prostatic Hyperplasia
Stromal Cells
Citation: Cell Biology International. v. 29, n. 9, p. 778-84, 2005-Sep.
Rights: fechado
Identifier DOI: 10.1016/j.cellbi.2005.05.003
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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