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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleLate Effects Of Chronic Graft-vs.-host Disease In Minor Salivary Glands.pt_BR
dc.contributor.authorAlborghetti, M Rpt_BR
dc.contributor.authorCorrêa, M E Ppt_BR
dc.contributor.authorAdam, R Lpt_BR
dc.contributor.authorMetze, Kpt_BR
dc.contributor.authorCoracin, F Lpt_BR
dc.contributor.authorde Souza, C Apt_BR
dc.contributor.authorCintra, M Lpt_BR
unicamp.authorM R Alborghetti, Department of Pathology, Medical School, State University of Campinas (UNICAMP), CEP 13081-970, Campinas-SP, Brazil.pt_BR
unicamp.author.externalM E P Corrêa,pt
unicamp.author.externalR L Adam,pt
unicamp.author.externalK Metze,pt
unicamp.author.externalF L Coracin,pt
unicamp.author.externalC A de Souza,pt
unicamp.author.externalM L Cintra,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectAnti-inflammatory Agentspt_BR
dc.subjectBiopsypt_BR
dc.subjectBone Marrow Transplantationpt_BR
dc.subjectCase-control Studiespt_BR
dc.subjectChronic Diseasept_BR
dc.subjectCyclosporinept_BR
dc.subjectFemalept_BR
dc.subjectGraft Vs Host Diseasept_BR
dc.subjectHumanspt_BR
dc.subjectImmunosuppressive Agentspt_BR
dc.subjectLeukemia, Myeloidpt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectPeriodic Acid-schiff Reactionpt_BR
dc.subjectPrednisonept_BR
dc.subjectSalivary Glands, Minorpt_BR
dc.subjectXerostomiapt_BR
dc.description.abstractThe established pathologic criteria for minor salivary gland (MSG) involvement in chronic graft-vs.-host disease (cGVHD) could play a role in monitoring response to therapy. We evaluated MSG sequential biopsies during cGVHD therapy in 14 allogeneic bone marrow transplantation (BMT) patients. Nine patients that did not develop GVHD after BMT entered the control group. Biopsies were examined using hematoxylin-eosin, Periodic acid-Schiff (PAS) and leukocyte common antigen staining. A significant loss of PAS+ acinar volume was observed at the diagnosis of cGVHD as much as at the end of treatment when compared with the control group. In the second evaluation, the inflammatory infiltrate was still greater than control group. The results suggest that persistent xerostomia after cGVHD treatment is because of maintenance of lymphocytic infiltrate and consequent absence of MSG secretory unit recovery. This data may be useful to provide improved insight into the histopathology of this organ involvement.en
dc.relation.ispartofJournal Of Oral Pathology & Medicine : Official Publication Of The International Association Of Oral Pathologists And The American Academy Of Oral Pathologypt_BR
dc.relation.ispartofabbreviationJ. Oral Pathol. Med.pt_BR
dc.date.issued2005-Seppt_BR
dc.identifier.citationJournal Of Oral Pathology & Medicine : Official Publication Of The International Association Of Oral Pathologists And The American Academy Of Oral Pathology. v. 34, n. 8, p. 486-93, 2005-Sep.pt_BR
dc.language.isoengpt_BR
dc.description.volume34pt_BR
dc.description.firstpage486-93pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0904-2512pt_BR
dc.identifier.doi10.1111/j.1600-0714.2005.00347.xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16091116pt_BR
dc.date.available2015-11-27T13:02:20Z-
dc.date.accessioned2015-11-27T13:02:20Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:02:20Z (GMT). No. of bitstreams: 1 pmed_16091116.pdf: 318437 bytes, checksum: b4b314413c5f0685c881c002d662087f (MD5) Previous issue date: 2005en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196367-
dc.identifier.idPubmed16091116pt_BR
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