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Type: Artigo de periódico
Title: Aspirin Inhibits Serine Phosphorylation Of Insulin Receptor Substrate 1 In Growth Hormone Treated Animals.
Author: Prattali, Raphael R
Barreiro, Guilherme C
Caliseo, Caio T
Fugiwara, Felipe Y
Ueno, Mirian
Prada, Patrícia O
Velloso, Licio A
Saad, Mario J A
Carvalheira, José B C
Abstract: In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRS/PI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance.
Subject: Adipose Tissue
Growth Hormone
Insulin Receptor Substrate Proteins
Jnk Mitogen-activated Protein Kinases
Proto-oncogene Proteins C-jun
Rats, Wistar
Receptor, Insulin
Citation: Febs Letters. v. 579, n. 14, p. 3152-8, 2005-Jun.
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2005.04.075
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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