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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleUncaria Tomentosa Extract Increases The Number Of Myeloid Progenitor Cells In The Bone Marrow Of Mice Infected With Listeria Monocytogenes.pt_BR
dc.contributor.authorEberlin, Samarapt_BR
dc.contributor.authordos Santos, Leonilda M Bpt_BR
dc.contributor.authorQueiroz, Mary L Spt_BR
unicamp.authorSamara Eberlin, Departamento de Farmacologia/Hemocentro, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), C.P. 6111, CEP 13083-970, Campinas, SP, Brazil.pt_BR
unicamp.author.externalLeonilda M B dos Santos,pt
unicamp.author.externalMary L S Queiroz,pt
dc.subjectAnimalspt_BR
dc.subjectBone Marrow Cellspt_BR
dc.subjectCat's Clawpt_BR
dc.subjectHematopoiesispt_BR
dc.subjectInterleukin-1pt_BR
dc.subjectInterleukin-6pt_BR
dc.subjectListeriosispt_BR
dc.subjectMalept_BR
dc.subjectMicept_BR
dc.subjectMice, Inbred Balb Cpt_BR
dc.subjectMyeloid Progenitor Cellspt_BR
dc.subjectPhytotherapypt_BR
dc.subjectPlant Extractspt_BR
dc.description.abstractIn this study, we demonstrated that Uncaria tomentosa extract (UTE) protects mice from a lethal dose of Listeria monocytogenes when administered prophylactically at 50, 100, 150 and 200 mg/kg for 7 days, with survival rates up to 35%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with L. monocytogenes, due to increased numbers of granulocyte-macrophage progenitors (CFU-GM) in the bone marrow. Non-infected mice treated with 100 mg/kg UTE also presented higher numbers of CFU-GM in the bone marrow than the controls. Investigation of the production of colony-stimulating factors revealed increased colony-stimulating activity (CSA) in the serum of normal and infected mice pre-treated with UTE. Moreover, stimulation of myelopoiesis and CSA occurred in a dose-dependent manner, a plateaux being reached with the dose of 100 mg/kg. Further studies to investigate the levels of factors such as IL-1 and IL-6 were undertaken. We observed increases in the levels of IL-1 and IL-6 in mice infected with L. monocytogenes and treated with 100 mg/kg of UTE. White blood cells (WBC) and differential counting were also performed, and our results demonstrated no significant changes in these data, when infected mice were pre-treated with 100 mg/kg of UTE. All together, our results suggest that UTE indirectly modulates immune activity and probably disengages Listeria-induced supression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow in consequence of biologically active cytokine release (CSFs, IL-1 and IL-6).en
dc.relation.ispartofInternational Immunopharmacologypt_BR
dc.relation.ispartofabbreviationInt. Immunopharmacol.pt_BR
dc.date.issued2005-Julpt_BR
dc.identifier.citationInternational Immunopharmacology. v. 5, n. 7-8, p. 1235-46, 2005-Jul.pt_BR
dc.language.isoengpt_BR
dc.description.volume5pt_BR
dc.description.firstpage1235-46pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1567-5769pt_BR
dc.identifier.doi10.1016/j.intimp.2005.03.001pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/15914328pt_BR
dc.date.available2015-11-27T13:02:09Z-
dc.date.accessioned2015-11-27T13:02:09Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:02:09Z (GMT). No. of bitstreams: 1 pmed_15914328.pdf: 160125 bytes, checksum: d799b03f0bae504cdbfa1bacb8219430 (MD5) Previous issue date: 2005en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196283-
dc.identifier.idPubmed15914328pt_BR
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