Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Bone Marrow Progenitor Cells From Chemically Exposed Workers Display An Intrinsic Ability For Autonomous Proliferation.
Author: Valadares, Marize Campos
Bincoletto, Claudia
Oliveira, Sueli C
de Melo, Adriana
Saad, Sara T O
Queiroz, Mary L S
Abstract: In this study, the autonomous proliferation of bone marrow progenitor cells (CFU-C), a pathological phenomenon observed in many hematological abnormalities, was investigated in 31 individuals who had been diagnosed as having neutropenia. Of these subjects, 18 had been chronically exposed (range of exposure 5-30 years) to a variety of petroleum distillates. We observed that the group of exposed individuals presented higher numbers of autonomous CFU-C when compared with those unexposed subjects. In addition, follow-up data demonstrated that 20% of the exposed population (4 of the 18) developed malignant hematological diseases. The autonomous CFU-C obtained from all individuals studied was composed predominantly of macrophages. This suggests an involvement of these cells in the development of hematological abnormalities, probably as a result of increased production of chemical myelotoxic metabolites.
Subject: Adult
Bone Marrow Cells
Cell Proliferation
Hematopoietic Stem Cells
Middle Aged
Occupational Exposure
Citation: Immunopharmacology And Immunotoxicology. v. 27, n. 1, p. 137-45, 2005.
Rights: fechado
Identifier DOI: 10.1081/IPH-51761
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_15803866.pdf468.29 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.