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Type: Artigo de periódico
Title: Importance Of Anesthesia For The Genesis Of Neurogenic Pulmonary Edema In Spinal Cord Injury.
Author: Leal Filho, Manoel Baldoino
Morandin, Rosana Celestina
de Almeida, Amanda Roberta
Cambiucci, Elizabeth Cristina
Borges, Guilherme
Gontijo, Jose Antonio Rocha
Metze, Konradin
Abstract: There are reports describing both provocation and inhibition of neurogenic pulmonary edema by anesthetic drugs. Therefore, we compared the effect of two types of anesthesia on the formation of neurogenic pulmonary edema in rats with balloon-induced acute spinal cord injury. Animals with sham procedure (group 1) were anesthesized by intraperitoneal sodium pentobarbital. In the experimental groups, rats were submitted to acute spinal cord lesion by insufflations of a balloon in the epidural space at T8 for 1 min (group 3 under i.p. sodium pentobarbital and group 2 under i.p. xylazine-ketamine anesthesia). In rats with pentobarbital anesthesia, systolic blood pressure doubled the baseline value during compression, whereas this effect was less pronounced in the ketamine-xylazine group. The pulmonary index (100 x wet lung weight/body weight) was 0.395 (+/-0.018) in sham-operated rats, rose to 0.499 (+/-0.060) in group 2, and was maximum under pentobarbital anesthesia (0.639+/-0.14; p=0.0018). Histologic examination of the spinal cord showed parenchymal ruptures and acute hemorrhage. Comparison of the pulmonary index with histologic slides of lung parenchyma revealed that relevant intra-alveolar edema occurred only for index values above 0.55. On electron microscopy, endothelial alterations, and damage of the alveolar lining cells were found. Our study indicates that neurogenic pulmonary edema caused by spinal cord injury is less pronounced in rats under xylazine-ketamine anesthesia, when compared with pentobarbital.
Subject: Anesthetics, General
Blood Pressure
Microscopy, Electron, Transmission
Pulmonary Edema
Spinal Cord Injuries
Citation: Neuroscience Letters. v. 373, n. 2, p. 165-70, 2005-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.neulet.2004.10.019
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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