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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleUndifferentiated Head And Neck Tumors: The Contribution Of Immunohistochemical Technique To Differential Diagnosis.pt_BR
dc.contributor.authorBianchini, Walter Adrianopt_BR
dc.contributor.authorAltemani, Albina Mariapt_BR
dc.contributor.authorPaschoal, Jorge Rizzatopt_BR
unicamp.authorWalter Adriano Bianchini, Department of Otorhinolaryngology, Hospital das Clínicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. ccoccp@terra.com.brpt_BR
unicamp.author.externalAlbina Maria Altemani,pt
unicamp.author.externalJorge Rizzato Paschoal,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectAgedpt_BR
dc.subjectAged, 80 And Overpt_BR
dc.subjectAntibodies, Monoclonalpt_BR
dc.subjectBrazilpt_BR
dc.subjectCell Differentiationpt_BR
dc.subjectCell Transformation, Neoplasticpt_BR
dc.subjectChildpt_BR
dc.subjectChild, Preschoolpt_BR
dc.subjectCross-sectional Studiespt_BR
dc.subjectDiagnosis, Differentialpt_BR
dc.subjectFemalept_BR
dc.subjectHead And Neck Neoplasmspt_BR
dc.subjectHumanspt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectRetrospective Studiespt_BR
dc.description.abstractUndifferentiated head and neck and skull base tumors are not unusual. They can arise in mucosa as well as in salivary glands, soft tissues or lymph nodes. Suitable therapy and prognosis for each case depends upon precise histopathological diagnosis. To evaluate the role of immunohistochemical techniques in determining the conclusive diagnosis. The occurrence of these tumors in our service and the way in which they were distributed according to cell pattern, patient's age and tumor location was also evaluated. Cross-sectional study. Hospital das Clínicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. 43 biopsies performed between January 1990 and December 1997, diagnosed as undifferentiated head and neck tumors. We applied an immunohistochemical panel in accordance with the avidin-biotin-peroxidase complex method. The final diagnosis was achieved after new analysis in conjunction with biopsies stained using the hematoxylin-eosin technique. This study evaluated undifferentiated tumors in head and neck, and the way in which they were distributed, according to cell pattern, patient's age and tumor location. The most frequent locations for undifferentiated tumors were the lymph nodes, 20.9%; pharynx and neck, 16.3%; paranasal sinus, 14%; and nose, 11.6%. They were most prevalent during the seventh decade of life (34.9%), and twice as prevalent in men as in women. The immunohistochemical technique allowed conclusive diagnosis for 60.5% of the tumors and was suggestive for 20.9% of the biopsies. The most prevalent cell pattern was round cells (51.2%), followed by epithelioid cells (20.9%), spindle cells (16.3%), myxoid pattern (9.3%) and pleomorphic cells (2.3%). Our results demonstrate the fundamental role of the immunohistochemical technique for conclusive diagnosis of undifferentiated tumors.en
dc.relation.ispartofSão Paulo Medical Journal = Revista Paulista De Medicinapt_BR
dc.relation.ispartofabbreviationSao Paulo Med Jpt_BR
dc.date.issued2003-Novpt_BR
dc.identifier.citationSão Paulo Medical Journal = Revista Paulista De Medicina. v. 121, n. 6, p. 244-7, 2003-Nov.pt_BR
dc.language.isoengpt_BR
dc.description.volume121pt_BR
dc.description.firstpage244-7pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1516-3180pt_BR
dc.identifier.doi/S1516-31802003000600005pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/14989140pt_BR
dc.date.available2015-11-27T12:58:45Z-
dc.date.accessioned2015-11-27T12:58:45Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:58:45Z (GMT). No. of bitstreams: 1 pmed_14989140.pdf: 156322 bytes, checksum: 4de2e3f5ae3dc8de5ec8a24149543fa7 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196133-
dc.identifier.idPubmed14989140pt_BR
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