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Type: Artigo de periódico
Title: Cell Death Evaluation In Benzo[a]pyrene-transformed Human Breast Epithelial Cells After Microcell-mediated Transfer Of Chromosomes 11 And 17.
Author: Mello, Maria Luiza S
Barbisan, Luis Fernando
Lareef, Mohamed H
Russo, Jose
Vidal, Benedicto de Campos
Abstract: The incidence of apoptosis and nuclear instability, including the incidence of catastrophic death, were investigated in benzo[a]pyrene (BP)-transformed human breast epithelial cells (BP1-E cell line) after microcell-mediated transfer of chromosomes 11 and 17. Since the introduction of normal chromosomes 11 and 17 into tumorigenic human breast BP1-E cells reverts some of these cells' characteristics (especially those affected by microsatellite instabilities and loss of heterozygosity) to those of parental non-transformed MCF-10F cells, it was expected that the cell death rates would also be affected by this treatment. The transfer of the mentioned chromosomes, especially chromosome 17, to tumorigenic BP1-E cells increased the apoptotic ratios and decreased the nuclear instability ratios, thus showing that the microsatellite instability and loss of heterozygosity induced by BP in these chromosomes of MCF-10F cells affect the control of cell death mechanisms.
Subject: Apoptosis
Cell Line, Transformed
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
Epithelial Cells
Citation: Mutation Research. v. 546, n. 1-2, p. 39-43, 2004-Feb.
Rights: fechado
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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