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Type: Artigo de periódico
Title: Normal Insulin Sensitivity In Lean Offspring Of Obese Parents.
Author: Lazarin, Mary A C T
Bennini, João R
Pereira, Carlos L C
Astiarraga, Brenno D
Ferrannini, Ele
Muscelli, Elza
Abstract: Offspring of diabetic or hypertensive patients are insulin resistant at a prediabetic/prehypertensive stage. We tested the hypothesis that insulin action may be impaired in the offspring of obese nondiabetic parents. Twenty-one lean offspring of nonobese subjects [(OL) 22 +/- 3 years of age] were matched to 23 lean offspring of obese subjects (OOb) by gender distribution, age, BMI, and waist circumference. Anthropometry, oral glucose tolerance, in vivo insulin sensitivity [by a euglycemic insulin clamp (6 pmol/min per kilogram(FFM); where FFM represents fat-free mass)], and thermogenesis (by indirect calorimetry) were measured in each subject. The study subjects were from a population of 267 nuclear families (one offspring and both his/her parents) in which there was statistically significant (chi2 = 30.2, p = 0.001) concordance of BMI between parents and offspring. In comparing OOb with OL, no statistically significant difference or trend toward a difference was detected in fasting plasma glucose and insulin concentrations, glucose and insulin responses to oral glucose, insulin sensitivity [metabolism value = 45 +/- 12 (OOb) vs. 47 +/- 17 micro mol/min per kilogram(FFM) (OL)], insulin-induced inhibition of protein and lipid oxidation, stimulation of glucose oxidation and nonoxidative glucose disposal, respiratory quotient, resting energy expenditure, and glucose-induced thermogenesis. The metabolic similarity between lean offspring of obese parents and those of nonobese parents suggests that insulin resistance and its correlates are not co-inherited with the predisposition to develop obesity.
Subject: Adult
Blood Glucose
Body Composition
Body Constitution
Body Mass Index
Glucose Clamp Technique
Glucose Tolerance Test
Insulin Resistance
Citation: Obesity Research. v. 12, n. 4, p. 621-6, 2004-Apr.
Rights: fechado
Identifier DOI: 10.1038/oby.2004.71
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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