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Type: Artigo de periódico
Title: Restored Insulin Inhibition On Insulin Secretion In Nondiabetic Severely Obese Patients After Weight Loss Induced By Bariatric Surgery.
Author: Pereira, J A
Claro, B M
Pareja, J C
Chaim, E A
Astiarraga, B D
Saad, M J A
Muscelli, E
Abstract: To examine the impact of important weight loss on insulin inhibition of its own secretion during experimentally induced hyperinsulinemia under euglycemic conditions. Longitudinal, clinical intervention study--bariatric surgery (vertical banded gastroplasty--gastric bypass--Capella technique), re-evaluation after 4 and 14 months. Nine obese patients class III (BMI=54.6+/-2.6 kg/m2) and nine lean subjects (BMI=22.7+/-0.7 kg/m2). Euglycemic hyperinsulinemic clamp (insulin infusion: 40 mU/min m2), C-peptide plasma levels, electrical bioimpedance methodology, and oral glucose tolerance test (OGTT). BMI was reduced in the follow-up: 44.5+/-2.2 and 33.9+/-1.5 kg/m2 at 4 and 14 months. Insulin-induced glucose uptake was markedly reduced in obese patients (19.5+/-1.9 micromol/min kg FFM) and improved with weight loss, but in the third study, it was still lower than that observed in controls (35.9+/-4.0 vs 52.9+/-2.2 micromol/min kg FFM). Insulin-induced inhibition of its own secretion was blunted in obese patients (19.9+/-5.7%, relative to fasting values), and completely reversed to values similar to that of lean ones in the second and third studies (-60.8+/-4.2 and -54.0+/-6.1%, respectively). Weight loss in severe obesity improved insulin-induced glucose uptake, and completely normalized the insulin inhibition on its own secretion.
Subject: Adult
Analysis Of Variance
Blood Glucose
Glucose Tolerance Test
Longitudinal Studies
Obesity, Morbid
Weight Loss
Citation: International Journal Of Obesity And Related Metabolic Disorders : Journal Of The International Association For The Study Of Obesity. v. 27, n. 4, p. 463-8, 2003-Apr.
Rights: fechado
Identifier DOI: 10.1038/sj.ijo.0802269
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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