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Type: Artigo de periódico
Title: The Prognostic Relevance Of Apoptosis-related Proteins In Classical Hodgkin's Lymphomas.
Author: Vassallo, José
Metze, Konradin
Traina, Fabíola
de Souza, Cármino A
Lorand-Metze, Irene
Abstract: Neoplastic cells in classical Hodgkin's lymphomas (cHL) seem to correspond to defective germinal center B-cells, which escape from apoptosis. Epstein-Barr virus (EBV) may be implicated in this protective mechanism. The aim of the present study was to determine the expression of apoptosis-related proteins in cHL among adult patients and correlate them with EBV expression, clinical findings and survival. EBV was detected by in situ hybridization (Epstein-Barr Encoded RNA, EBER, probe). Immunohistochemistry was used on paraffin sections to detect LMP-1/EBV, CD15 and the apoptosis-related proteins (bcl-2, bax, bcl-X, mcl-1 and CD95). Seventy-eight patients seen at our Institution were studied: 36 male and 42 female. Median age was 31 years (15-75 years). Histological types of cHL were: 61 nodular sclerosis (47 NS1 and 14 NS2), 15 mixed cellularity (MC), 1 lymphocyte depletion and 1 unclassified. In 50 cases there was EBV expression (64%). At least one apoptosis-associated protein was expressed in 92% and CD15 in 57.7% of the cases. In the univariate analysis, the following variables were related to a better overall survival: expression of CD15 (p = 0.023), expression of mcl-1 protein (p = 0.029), expression of bcl-2 protein (p = 0.028, only in a Cox model after stratification for histology) and expression of LMP-1 (p = 0.042). EBV expression presented a borderline inverse correlation with bcl-2. A prognostic index (PI) developed in the present study revealed that simultaneous expression of bcl-2, mcl-1 and LMP-1 was significant and independently correlated with an excellent survival.
Subject: Adolescent
Antigens, Cd15
Antigens, Cd95
Biological Markers
Epstein-barr Virus Infections
Hodgkin Disease
Life Tables
Middle Aged
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins
Proportional Hazards Models
Proto-oncogene Proteins
Proto-oncogene Proteins C-bcl-2
Rna, Viral
Retrospective Studies
Survival Analysis
Tumor Virus Infections
Viral Matrix Proteins
Bcl-2-associated X Protein
Bcl-x Protein
Citation: Leukemia & Lymphoma. v. 44, n. 3, p. 483-8, 2003-Mar.
Rights: fechado
Identifier DOI: 10.1080/1042819021000037958
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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