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Type: Artigo de periódico
Title: Programmed Cell Death In Thymus During Experimental Paracoccidioidomycosis.
Author: Souto, Paula C S
Brito, Vânia N
Gameiro, Jacy
da Cruz-Höfling, Maria Alice
Verinaud, Liana
Abstract: Many works have shown that immunosuppressive effects induced by systemic mycosis can be related to primary lymphoid organ damage. Previous studies in our laboratory showed that Paracoccidioides brasiliensis was able to invade the thymus, inducing a severe atrophy with significant reduction of cortical area along with a loss of cortico-medullary boundary. The objective of the present study was to investigate whether thymic atrophy is caused by programmed cell death (PCD) and to examine the ultrastructural characteristics of the thymus in experimentally infected BALB/c mice. The results revealed an eightfold increase in the apoptotic index occurring by day 5 post infection, i.e., during early stages of the infection, shown by immunohistochemistry. In addition, typical cell alterations of autophagic PCD were observed by transmission electron microscopy. Taken together, these results reinforce the idea that thymic alterations may be involved in the immunosuppressive phenomenon frequently associated with paracoccidioidomycotic infection.
Subject: Animals
Disease Models, Animal
In Situ Nick-end Labeling
Mice, Inbred Balb C
Microscopy, Electron
Thymus Gland
Citation: Medical Microbiology And Immunology. v. 192, n. 4, p. 225-9, 2003-Nov.
Rights: fechado
Identifier DOI: 10.1007/s00430-003-0180-3
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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