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dc.typeArtigo de periódicopt_BR
dc.titleA Leucine-supplemented Diet Improved Protein Content Of Skeletal Muscle In Young Tumor-bearing Rats.pt_BR
dc.contributor.authorGomes-Marcondes, M C Cpt_BR
dc.contributor.authorVentrucci, Gpt_BR
dc.contributor.authorToledo, M Tpt_BR
dc.contributor.authorCury, Lpt_BR
dc.contributor.authorCooper, J Cpt_BR
unicamp.authorM C C Gomes-Marcondes, Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil. cintgoma@unicamp.brpt_BR Ventrucci,pt T Toledo,pt Cury,pt C Cooper,pt
dc.subjectBody Compositionpt_BR
dc.subjectBody Weightpt_BR
dc.subjectCarcinoma 256, Walkerpt_BR
dc.subjectDietary Supplementspt_BR
dc.subjectMuscle Proteinspt_BR
dc.subjectMuscle, Skeletalpt_BR
dc.subjectRats, Wistarpt_BR
dc.description.abstractCancer cachexia induces host protein wastage but the mechanisms are poorly understood. Branched-chain amino acids play a regulatory role in the modulation of both protein synthesis and degradation in host tissues. Leucine, an important amino acid in skeletal muscle, is higher oxidized in tumor-bearing animals. A leucine-supplemented diet was used to analyze the effects of Walker 256 tumor growth on body composition in young weanling Wistar rats divided into two main dietary groups: normal diet (N, 18% protein) and leucine-rich diet (L, 15% protein plus 3% leucine), which were further subdivided into control (N or L) or tumor-bearing (W or LW) subgroups. After 12 days, the animals were sacrificed and their carcass analyzed. The tumor-bearing groups showed a decrease in body weight and fat content. Lean carcass mass was lower in the W and LW groups (W = 19.9 0.6, LW = 23.1 1.0 g vs N = 29.4 1.3, L = 28.1 1.9 g, P < 0.05). Tumor weight was similar in both tumor-bearing groups fed either diet. Western blot analysis showed that myosin protein content in gastrocnemius muscle was reduced in tumor-bearing animals (W = 0.234 0.033 vs LW = 0.598 0.036, N = 0.623 0.062, L = 0.697 0.065 arbitrary intensity, P < 0.05). Despite accelerated tumor growth, LW animals exhibited a smaller reduction in lean carcass mass and muscle myosin maintenance, suggesting that excess leucine in the diet could counteract, at least in part, the high host protein wasting in weanling tumor-bearing rats.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 36, n. 11, p. 1589-94, 2003-Nov.pt_BR
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