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Type: Artigo de periódico
Title: Crotapotin Induced Modification Of T Lymphocyte Proliferative Response Through Interference With Pge2 Synthesis.
Author: Garcia, Flavia
Toyama, Marcos H
Castro, Fabiano R
Proença, Patrícia L
Marangoni, Sergio
Santos, Leonilda M B
Abstract: The immunosuppressive property has been demonstrated for the venom of the Crotalus durissus terrificus. Using a simple, novel method for obtaining crotapotin and phospholipase A2 isoforms from venom, it was possible to demonstrate that the addition of crotapotin to cultures of isolated lymphocytes resulted in a significant inhibition of the cellular proliferative response to Concanavalin A. This reduction in blastogenic response of lymphocytes is accompanied by a significant increase in the production of PGE2 by macrophages. This effect on the innate immune response suggests that this compound may modify the subsequent adaptative immune response.
Subject: Animals
Enzyme Inhibitors
Immunity, Cellular
Immunosuppressive Agents
In Vitro Techniques
Lymphocyte Activation
Mice, Inbred Strains
Phospholipases A
Phospholipases A2
Citation: Toxicon : Official Journal Of The International Society On Toxinology. v. 42, n. 4, p. 433-7, 2003-Sep.
Rights: fechado
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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