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Type: Artigo de periódico
Title: Costimulatory Molecule Expression On Leukocytes From Mice With Experimental Autoimmune Encephalomyelitis Treated With Ifn-beta.
Author: Hallal, Dannie E M
Farias, Alessandro S
Oliveira, Elaine C
Diaz-Bardales, Blanca Maria
Brandão, Carlos Otavio
Protti, Gustavo G
Pereira, Fernanda G
Metze, Irene L
Santos, Leonilda M B
Abstract: Interferon-beta (IFN-beta) is of benefit in the treatment of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), but the mechanisms by which it exerts this beneficial effect remain uncertain. The present data demonstrate that IFN-beta therapy impairs the proliferative response to concanavalin A (ConA) and myelin basic protein (MBP), decreases expression of the CD80 molecule on leukocytes of treated mice, and may thereby impede the Th1 cell activation-promoting anergy in EAE. Moreover, IFN-beta therapy increases expression of the CTLA4 molecule, which induces a counterregulatory Th2 response. The reduction of CD80 expression with concomitant increase of CTLA4 expression alters the course of EAE and may be useful as a monitor in therapy with IFN-beta.
Subject: Animals
Antigens, Cd
Antigens, Cd80
Antigens, Differentiation
Ctla-4 Antigen
Encephalomyelitis, Autoimmune, Experimental
Lymphocyte Activation
Multiple Sclerosis
Citation: Journal Of Interferon & Cytokine Research : The Official Journal Of The International Society For Interferon And Cytokine Research. v. 23, n. 6, p. 293-8, 2003-Jun.
Rights: fechado
Identifier DOI: 10.1089/107999003766628133
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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