Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195445
Type: Artigo de periódico
Title: Hypertrophic Lupus Erythematosus: A Clinicopathological Study Of 14 Cases.
Author: Daldon, Patrícia Erica Christofoletti
Macedo de Souza, Elemir
Cintra, Maria Letícia
Abstract: Hypertrophic lupus erythematosus (HLE) is a distinct and rare subset of lupus erythematosus (LE). It is characterized by verrucous lesions, chronic in its course, and resistant to treatment. The purpose of this study was to identify clinical and histological characteristics of HLE. We review our experience with 14 cases of HLE identified in a group of 220 patients with different forms of LE, at the UNICAMP Hospital, between 1976 and 2002. All patients presented verrucous plaques concomitantly with discoid lesions. The most common sites of involvement were the face and the arms. Histology of HLE lesions revealed pseudoepitheliomatous hyperplasia engulfing elastotic material. Elastic fibers were seen in migration throughout the epidermis. Classic features of LE were noted in all cases. Three of the patients developed hyperkeratotic papules with central keratinous plug on their arms at the previous LE sites. These lesions resemble clinically and histopathologically keratoacanthomas. In one patient, HLE lesion progressed to squamous cell carcinoma (SCC), 26 years after the onset of the disease. Transepithelial elimination of the elastotic material may be a feature of HLE. Some HLE lesions may present as keratoacanthoma, but classical features of LE aid the correct diagnosis. SCC may arise on a long-standing HLE lesion; therefore HLE requires clinical and histopathological follow up.
Subject: Adult
Brazil
Female
Follow-up Studies
Hospitals, University
Humans
Hyperplasia
Hypertrophy
Lupus Erythematosus, Discoid
Male
Middle Aged
Retrospective Studies
Skin
Citation: Journal Of Cutaneous Pathology. v. 30, n. 7, p. 443-8, 2003-Aug.
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/12859742
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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