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Type: Artigo de periódico
Title: Modulation Of Ir/ptp1b Interaction And Downstream Signaling In Insulin Sensitive Tissues Of Msg-rats.
Author: Hirata, Aparecida Emiko
Alvarez-Rojas, Fernanda
Carvalheira, José Barreto Campello
Carvalho, Carla Roberta de Oliveira
Dolnikoff, Miriam Sterman
Abdalla Saad, Mario José
Abstract: PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance.
Subject: Adipose Tissue
Animals, Newborn
Insulin Receptor Substrate Proteins
Insulin Resistance
Intracellular Signaling Peptides And Proteins
Muscle, Skeletal
Phosphatidylinositol 3-kinases
Protein Tyrosine Phosphatase, Non-receptor Type 1
Protein Tyrosine Phosphatases
Protein-serine-threonine Kinases
Proto-oncogene Proteins
Proto-oncogene Proteins C-akt
Rats, Wistar
Receptor, Insulin
Signal Transduction
Sodium Glutamate
Citation: Life Sciences. v. 73, n. 11, p. 1369-81, 2003-Aug.
Rights: fechado
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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