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Type: Artigo de periódico
Title: Quality Of Life In Patients Randomized To Receive A Bone Marrow Or A Peripheral Blood Allograft.
Author: De Souza, Carmino Antonio
Durães, Margareth I C
Vigorito, Afonso Celso
Penteado Aranha, Francisco José
Oliveira, Gislaine Barbosa
De Brito Eid, Kátia A
Zulli, Roberto
Cristina, Eliana
Miranda, Martins
Botega, Neury José
Abstract: Quality of life (QOL) is an important clinical end-point to be considered in the late follow-up of patients treated with allogeneic bone marrow (BM) or peripheral blood progenitor cell (PBPC) transplantation. To assess the QOL in a group of survivors of hematologic malignancies who had been enrolled in a prospective randomized trial comparing allogeneic BM with PBPC. Sixty randomized patients had been enrolled in a study comparing BM with PBPC graft during 1995-99. At the time of this QOL study, 30 were alive and 26 (13 BM and 13 PBPC) were eligible. Clinical and demographic data were collected and psychometric instruments (WHOQOL-100 and the Hospital Anxiety and Depression Scale HAD) were used. Non-parametric and univariate analyses were performed. The PBPC recipients had more chronic graft-versus-host disease (p=0.03) and were on immunosuppressive treatment for a longer period (p=0.02). The WHOQOL-100 analysis demonstrated significant differences between groups with more favorable results in the BM group in the facets of Pain and Discomfort (p=0.03), Mobility (p=0.02) and Daily Living Activities (p=0.03). According to the patients' spontaneous responses, 8 individuals (6 in the PBPC group) believed that their QOL had worsened. With the limitations of a small randomized study, these findings suggest a lower QOL in recipients of allogeneic PBPC than in recipients of BM grafts, probably due to the frequency and severity of chronic graft-versus-host disease. This need to be confirmed in a large international trial.
Subject: Adult
Bone Marrow Transplantation
Follow-up Studies
Graft Vs Host Disease
Middle Aged
Peripheral Blood Stem Cell Transplantation
Prospective Studies
Quality Of Life
Transplantation, Homologous
Citation: Haematologica. v. 87, n. 12, p. 1281-5, 2002-Dec.
Rights: aberto
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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