Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195122
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePlasma Glucose Regulation And Insulin Secretion In Hypertriglyceridemic Mice.pt_BR
dc.contributor.authorAmaral, M E Cpt_BR
dc.contributor.authorOliveira, H C Fpt_BR
dc.contributor.authorCarneiro, E Mpt_BR
dc.contributor.authorDelghingaro-Augusto, Vpt_BR
dc.contributor.authorVieira, E Cpt_BR
dc.contributor.authorBerti, J Apt_BR
dc.contributor.authorBoschero, A Cpt_BR
unicamp.authorM E C Amaral, Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109 Campinas, SP, 13083-970 Brazil.pt_BR
unicamp.author.externalH C F Oliveira,pt
unicamp.author.externalE M Carneiro,pt
unicamp.author.externalV Delghingaro-Augusto,pt
unicamp.author.externalE C Vieira,pt
unicamp.author.externalJ A Berti,pt
unicamp.author.externalA C Boschero,pt
dc.subjectAnimalspt_BR
dc.subjectApolipoprotein C-iiipt_BR
dc.subjectApolipoproteins Cpt_BR
dc.subjectArea Under Curvept_BR
dc.subjectBlood Glucosept_BR
dc.subjectBody Weightpt_BR
dc.subjectCholesterolpt_BR
dc.subjectFatty Acids, Nonesterifiedpt_BR
dc.subjectFemalept_BR
dc.subjectGlucose Tolerance Testpt_BR
dc.subjectHeparinpt_BR
dc.subjectHypertriglyceridemiapt_BR
dc.subjectInsulinpt_BR
dc.subjectIslets Of Langerhanspt_BR
dc.subjectMalept_BR
dc.subjectMicept_BR
dc.subjectMice, Transgenicpt_BR
dc.subjectStatistics, Nonparametricpt_BR
dc.subjectTriglyceridespt_BR
dc.description.abstractIn this study, we examined glucose homeostasis and insulin secretion in transgenic mice overexpressing the human apolipoprotein CIII gene (apo CIII tg). These mice have elevated plasma levels of triglycerides, FFA and cholesterol compared to control mice. The body weight, plasma glucose, and insulin levels, glucose disappearance rates, areas under the ipGTT curve for adult (4 - 8 mo. old) and aged (20 - 24 mo. old) apo CIII tg mice and the determination of insulin during the ipGTT were not different from those of control mice. However, an additional elevation of plasma FFA by treatment with heparin for 2 - 4 h impaired the ipGTT responses in apo CIII tg mice compared to saline-treated mice. The glucose disappearance rate in heparin-treated transgenic mice was slightly lower than in heparin-treated controls. Glucose (22.2 mmol/l) stimulated insulin secretion in isolated islets to the same extent in saline-treated control and apo CIII tg mice. In islets from heparin-treated apo CIII tg mice, the insulin secretion at 2.8 and 22.2 mmol glucose/l was lower than in heparin-treated control mice. In conclusion, hypertriglyceridemia per se or a mild elevation in FFA did not affect insulin secretion or insulin resistance in adult or aged apo CIII tg mice. Nonetheless, an additional elevation of FFA induced by heparin in hypertriglyceridemic mice impaired the ipGTT by reducing insulin secretion.en
dc.relation.ispartofHormone And Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolismept_BR
dc.relation.ispartofabbreviationHorm. Metab. Res.pt_BR
dc.date.issued2002-Janpt_BR
dc.identifier.citationHormone And Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme. v. 34, n. 1, p. 21-6, 2002-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume34pt_BR
dc.description.firstpage21-6pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0018-5043pt_BR
dc.identifier.doi10.1055/s-2002-19962pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/11832997pt_BR
dc.date.available2015-11-27T12:49:14Z-
dc.date.accessioned2015-11-27T12:49:14Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:49:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2002en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195122-
dc.identifier.idPubmed11832997pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.