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dc.typeArtigo de periódicopt_BR
dc.titleCharacterization Of The Hypotensive Effect Of S-nitroso-n-acetylcysteine In Normotensive And Hypertensive Conscious Rats.pt_BR
dc.contributor.authorRicardo, Kelly Fabiane Santospt_BR
dc.contributor.authorShishido, Sílvia Mikapt_BR
dc.contributor.authorde Oliveira, Marcelo Ganzarollipt_BR
dc.contributor.authorKrieger, Marta Helenapt_BR
unicamp.authorKelly Fabiane Santos Ricardo, Departamento de Fisiologia e Biofísica, Instituto de Biologia, C.P. 6109, UNICAMP, CEP 13083-970, Campinas, São Paulo, Brazil.pt_BRílvia Mika Shishido,pt Ganzarolli de Oliveira,pt Helena Krieger,pt
dc.subjectBlood Pressurept_BR
dc.subjectCyclic Gmppt_BR
dc.subjectDose-response Relationship, Drugpt_BR
dc.subjectDrug Stabilitypt_BR
dc.subjectDrug Synergismpt_BR
dc.subjectDrug Therapy, Combinationpt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectSulfhydryl Compoundspt_BR
dc.description.abstractS-Nitrosothiols (RSNOs) are potent vasodilators found naturally in vivo. A variety of synthetic RSNOs have been considered as potential nitric oxide (NO) donors for biomedical applications. We have characterized the hypotensive effect of the RSNO S-nitroso-N-acetylcysteine (SNAC) in normotensive and hypertensive conscious rats. SNAC reduced the medium arterial pressure in a dose-response manner in both normotensive and hypertensive animals. At the same doses (EC(50) of SNAC), SNAC showed a vasodilator effect in normotensive rats more potent and more prolonged than that of sodium nitroprusside (SNP). The hypotensive effect of SNAC was also more potent in methylene blue-treated rats, where the cGMP-dependent pathway had been blockaded. These data indicate that SNAC acts by both cGMP-dependent and cGMP-independent pathways. It was also shown that the thiol N-acetylcysteine (NAC) potentiates the action of SNP in hypertensive rats, pointing to the mediation of thiols in the vasodilator action of SNP in this condition. Such mediation may involve the formation of a more potent thiol complex with the nitroprusside anion or the transfer of NO to NAC, generating SNAC as a primary vasoactive species. The kinetic monitoring of the decomposition reactions of SNAC and SNP showed that both compounds are quite stable under the infusion conditions used. Therefore, their vasodilator action cannot be assigned to their breakdown with release of free NO in solution. As the two compounds are unlikely to cross the plasmalemma of smooth muscle cells, their actions are probably associated with the mediation of endogenous thiols in transnitrosation reactions.en
dc.relation.ispartofNitric Oxide : Biology And Chemistry / Official Journal Of The Nitric Oxide Societypt_BR
dc.relation.ispartofabbreviationNitric Oxidept_BR
dc.identifier.citationNitric Oxide : Biology And Chemistry / Official Journal Of The Nitric Oxide Society. v. 7, n. 1, p. 57-66, 2002-Aug.pt_BR
dc.rights.holderCopyright 2002 Elsevier Science (USA)pt_BR
dc.description.provenanceMade available in DSpace on 2015-11-27T12:49:12Z (GMT). No. of bitstreams: 1 pmed_12175821.pdf: 307495 bytes, checksum: 838a6068aeb7864f8bc2b937ca1519ec (MD5) Previous issue date: 2002en
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