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Type: Artigo de periódico
Title: A New Inorganic Vasodilator, Trans-[ru(no)(nh(3))(4)(poet)(3)](pf(6))(3): Hypotensive Effect Of Endothelium-dependent And -independent Vasodilators In Different Hypertensive Animals Models.
Author: de Barros, Brígida Figueiredo
Toledo, José Carlos
Franco, Douglas Wagner
Tfouni, Elia
Krieger, Marta Helena
Abstract: The hypotensive effect of RuNO was investigated in acute and chronic hypertensive rats, as well as in normotensive rats. Acute hypertension rats were used with 30% increase on basal BP (phenylephrine, angiotensin II (Ang II), N(G)-nitro-L-arginine methyl ester (L-NAME), and adult spontaneously hypertensive rats (SHR) (basal BP 168 +/- 3 mm Hg) were used as models for chronic hypertension. Rats were implanted with catheters (iv/ia) for BP measurements and for in bolus administration of RuNO, sodium nitroprusside (SNP), and acetylcholine (Ach) (10, 20, 40 nmol/kg, iv). The principal findings of this study were: (i) The hypotensive response to RuNO was 150% higher in acutely (phenylephrine and Ang II) and chronically (SHR) hypertensive rats than in normotensive rats, except in the case of L-NAME-induced hypertension (deltaMAP = 10 +/- 1.4 mm Hg). Chronic SHR showed 60% increase (deltaMAP = 19 +/- 0.8 mm Hg) in the effect compared to normotensive rats. (ii) The hypotensive response to SNP was lower (60%) in hypertensive rats than in normotensive rats, when compared to RuNO. However, the responses were similar in L-NAME-induced hypertension (deltaMAP = 30 +/- 2 mm Hg). (iii) The vasodilator response to Ach was increased in rats with Ang II-induced hypertension (deltaMAP = 53 +/- 1 mm Hg) and in SHR (deltaMAP = 67 +/- 3 mm Hg). RuNO response was more potent than SNP in hypertensive models and the increment in relation to normotensive was observed in the phenylephrine- and L-NAME-treated rats. This response could be correlated to the different endothelial dysfunction present in each model.
Subject: Acetylcholine
Blood Pressure
Disease Models, Animal
Endothelium, Vascular
Nitric Oxide Donors
Organometallic Compounds
Rats, Wistar
Ruthenium Compounds
Vasodilator Agents
Citation: Nitric Oxide : Biology And Chemistry / Official Journal Of The Nitric Oxide Society. v. 7, n. 1, p. 50-6, 2002-Aug.
Rights: fechado
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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