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Type: Artigo de periódico
Title: Expression Of Neuronal Isoform Of Nitric Oxide Synthase In Spinal Neurons Of Neonatal Rats After Sciatic Nerve Transection.
Author: Rogério, F
Teixeira, S A
de Souza Queiroz, L
De Nucci, G
Langone, F
Abstract: Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of the neuronal isoform of nitric oxide synthase (nNOS), a diaphorase of which one of the cofactors is nicotinamide adenine dinucleotide phosphate (NADPH). We transected the sciatic nerve of neonatal rats (P2) and examined nNOS expression by immunostaining in neurons of the sciatic pool and of other spinal levels on the 5th day after surgery. No correspondence was observed between the surviving motoneurons and nNOS positive cells. The appearance and distribution of nNOS positive neurons at all spinal levels and laminae were similar to those of adult animals. These results are at variance with previous studies which showed correlation between motoneuron loss after axotomy and number of NADPH-diaphorase positive motoneurons after sciatic transection.
Subject: Animals
Animals, Newborn
Cell Count
Motor Neurons
Nadph Dehydrogenase
Nitric Oxide
Nitric Oxide Synthase
Oxidative Stress
Protein Isoforms
Rats, Wistar
Retrograde Degeneration
Sciatic Nerve
Spinal Cord
Citation: Neuroscience Letters. v. 307, n. 2, p. 61-4, 2001-Jul.
Rights: fechado
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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