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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHigh Prevalence Of Alpha-thalassemia Among Individuals With Microcytosis And Hypochromia Without Anemia.pt_BR
dc.contributor.authorBorges, Ept_BR
dc.contributor.authorWenning, M Rpt_BR
dc.contributor.authorKimura, E Mpt_BR
dc.contributor.authorGervásio, S Apt_BR
dc.contributor.authorCosta, F Fpt_BR
dc.contributor.authorSonati, M Fpt_BR
unicamp.authorE Borges, Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, 13083-970 Campinas, SP, Brazil.pt_BR
unicamp.author.externalM R Wenning,pt
unicamp.author.externalE M Kimura,pt
unicamp.author.externalS A Gervásio,pt
unicamp.author.externalF F Costa,pt
unicamp.author.externalM F Sonati,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectBrazilpt_BR
dc.subjectContinental Population Groupspt_BR
dc.subjectErythrocyte Indicespt_BR
dc.subjectErythrocytes, Abnormalpt_BR
dc.subjectFemalept_BR
dc.subjectFerritinspt_BR
dc.subjectGene Deletionpt_BR
dc.subjectGenotypept_BR
dc.subjectHemoglobinspt_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectPrevalencept_BR
dc.subjectAlpha-thalassemiapt_BR
dc.description.abstractIn order to determine the contribution of alpha-thalassemia to microcytosis and hypochromia, 339 adult outpatients seen at Unicamp University Hospital (with the exception of the Clinical Hematology outpatient clinics), who showed normal hemoglobin (Hb) levels and reduced mean corpuscular volume and mean corpuscular hemoglobin, were analyzed. Ninety-eight were Blacks (28.9%) and 241 were Caucasians (71.1%). In all cases, Hb A2 and F levels were either normal or low. The most common deletional and nondeletional forms of alpha-thalassemia [-alpha3.7, -alpha4.2, --MED, -(alpha)20.5, alphaHphIalpha, alphaNcoIalpha, alphaalphaNcoI and alphaTSAUDI] were investigated by PCR and restriction enzyme analyses. A total of 169 individuals (49.9%) presented alpha-thalassemia: 145 (42.8%) were heterozygous for the -alpha3.7 deletion (-alpha3.7/alphaalpha) and 18 (5.3%) homozygous (-alpha3.7/-alpha3.7), 5 (1.5%) were heterozygous for the nondeletional form alphaHphIalpha (alphaHphIalpha/alphaalpha), and 1 (0.3%) was a --MED carrier (--MED/alphaalpha). Among the Blacks, 56 (57.1%) showed the -alpha3.7/alphaalpha genotype, whereas 12 (12.2%) were -alpha3.7/-alpha3.7 and 1 (1.0%) was an alphaHphIalpha carrier; among the Caucasians, 89 (36.9%) were -alpha3.7/alphaalpha, 6 (2.5%) had the -alpha3.7/-alpha3.7 genotype, 4 (1.7%) presented the nondeletional form (alphaHphIalpha/alphaalpha), and 1 (0.4%) was a --MED carrier. These results demonstrate that alpha-thalassemia, mainly through the -alpha3.7 deletion, is an important cause of microcytosis and hypochromia in individuals without anemia. These data are of clinical relevance since these hematological alterations are often interpreted as indicators of iron deficiency.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.date.issued2001-Junpt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 34, n. 6, p. 759-62, 2001-Jun.pt_BR
dc.language.isoengpt_BR
dc.description.volume34pt_BR
dc.description.firstpage759-62pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/11378664pt_BR
dc.date.available2015-11-27T12:29:17Z-
dc.date.accessioned2015-11-27T12:29:17Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:29:17Z (GMT). No. of bitstreams: 1 pmed_11378664.pdf: 179734 bytes, checksum: eeee003ddb9abe2ef871654f6d16576c (MD5) Previous issue date: 2001en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195008-
dc.identifier.idPubmed11378664pt_BR
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