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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHsp72 As A Complementary Protection Against Oxidative Stress Induced By Exercise In The Soleus Muscle Of Rats.pt_BR
dc.contributor.authorSmolka, M Bpt_BR
dc.contributor.authorZoppi, C Cpt_BR
dc.contributor.authorAlves, A Apt_BR
dc.contributor.authorSilveira, L Rpt_BR
dc.contributor.authorMarangoni, Spt_BR
dc.contributor.authorPereira-Da-Silva, Lpt_BR
dc.contributor.authorNovello, J Cpt_BR
dc.contributor.authorMacedo, D Vpt_BR
unicamp.authorM B Smolka, Departamento de Bioquímica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, São Paulo 13083 - 970, Brazil.pt_BR
unicamp.author.externalC C Zoppi,pt
unicamp.author.externalA A Alves,pt
unicamp.author.externalL R Silveira,pt
unicamp.author.externalS Marangoni,pt
unicamp.author.externalL Pereira-Da-Silva,pt
unicamp.author.externalJ C Novello,pt
unicamp.author.externalD V Macedo,pt
dc.subjectAnimalspt_BR
dc.subjectCatalasept_BR
dc.subjectCitrate (si)-synthasept_BR
dc.subjectGlutathione Reductasept_BR
dc.subjectHsp72 Heat-shock Proteinspt_BR
dc.subjectHeat-shock Proteinspt_BR
dc.subjectMalept_BR
dc.subjectMuscle Contractionpt_BR
dc.subjectMuscle, Skeletalpt_BR
dc.subjectOxidative Stresspt_BR
dc.subjectPhysical Exertionpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.description.abstractGiven the potential of reactive oxygen species to damage intracellular proteins during subsequent bouts of muscle contractions, it was suggested that, when this production exceeds the antioxidant capacity, the preexisting antioxidant pathways may be complemented by the synthesis of the defense mechanism represented by heat shock proteins (HSPs), stress proteins with the function of repair and maintaining protein folding. To test this hypothesis, we analyzed reactive carbonyl derivatives in plasma and the expression of HSP72 and activities of enzymes from the oxidative and antioxidant defense systems in the soleus muscle of sedentary rats and rats trained by two protocols: continuous and intermittent. We analyzed all three groups at rest and 2 h after acute exercise. After 8 wk of training, the animals from both groups clearly demonstrated higher resistance to exercise. Both trained groups showed significantly higher citrate synthase, catalase, and glutathione reductase activities than the control group (P < 0.01). After acute exercise, catalase and glutathione reductase activities significantly decreased (P < 0.01) and plasma reactive carbonyl derivatives significantly increased (P < 0.05) in the sedentary group, suggesting an oxidative-stress condition as responsible for exhaustion in this group. Finally, after acute exercise, the induction of HSP72 expression occurred only in the sedentary group, suggesting that HSP72 acts as a complementary protective mechanism in exercise-induced oxidative stress.en
dc.relation.ispartofAmerican Journal Of Physiology. Regulatory, Integrative And Comparative Physiologypt_BR
dc.relation.ispartofabbreviationAm. J. Physiol. Regul. Integr. Comp. Physiol.pt_BR
dc.date.issued2000-Novpt_BR
dc.identifier.citationAmerican Journal Of Physiology. Regulatory, Integrative And Comparative Physiology. v. 279, n. 5, p. R1539-45, 2000-Nov.pt_BR
dc.language.isoengpt_BR
dc.description.volume279pt_BR
dc.description.firstpageR1539-45pt_BR
dc.rightsfechadopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0363-6119pt_BR
dc.identifier.doipt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/11049834pt_BR
dc.date.available2015-11-27T12:22:44Z-
dc.date.accessioned2015-11-27T12:22:44Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:22:44Z (GMT). No. of bitstreams: 1 pmed_11049834.pdf: 176240 bytes, checksum: eb9e22d9a98e04638ba3551cd80726e3 (MD5) Previous issue date: 2000en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194613-
dc.identifier.idPubmed11049834pt_BR
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