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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleGenetic And Environmental Influences On Atopic Immune Response In Early Life.pt_BR
dc.contributor.authorLópez, Npt_BR
dc.contributor.authorde Barros-Mazón, Spt_BR
dc.contributor.authorVilela, M Mpt_BR
dc.contributor.authorSilva, C Mpt_BR
dc.contributor.authorRibeiro, J Dpt_BR
unicamp.authorN López, Department of Pediatrics, State University of Campinas (UNICAMP), Brazil.pt_BR
unicamp.author.externalS de Barros-Mazón,pt
unicamp.author.externalM M Vilela,pt
unicamp.author.externalC M Silva,pt
unicamp.author.externalJ D Ribeiro,pt
dc.subjectBreast Feedingpt_BR
dc.subjectCohort Studiespt_BR
dc.subjectContinental Population Groupspt_BR
dc.subjectFamily Healthpt_BR
dc.subjectFemalept_BR
dc.subjectFetal Bloodpt_BR
dc.subjectHumanspt_BR
dc.subjectHypersensitivity, Immediatept_BR
dc.subjectImmunoglobulin Ept_BR
dc.subjectInfantpt_BR
dc.subjectInfant, Newbornpt_BR
dc.subjectMalept_BR
dc.subjectPregnancypt_BR
dc.subjectProspective Studiespt_BR
dc.subjectSex Factorspt_BR
dc.subjectSmokingpt_BR
dc.description.abstractThe purpose of our study was to carry out a prospective follow-up of 114 newborns at term (including three pairs of twins), regarding clinical manifestations for atopy during the first year of life. Their IgE levels in cord blood samples, at 3, 6, 9 and 12 months of age were measured and the influence of race, sex, breast-feeding, maternal smoking, family income, month of birth, family history and personal manifestations of atopic disease were evaluated. Total serum immunoglobulin E was quantified by microparticle enzyme immuno-assay (MEIA). The study group consisted of 60 (53%) male neonates, 67 (59%) Caucasians and 47 (41%) blacks. In the clinical follow-up, 32 (28.1%) infants developed obvious atopic disease: 29 infants presented recurrent wheezing, two had cow's milk allergy and one had atopic dermatitis. Probable atopic disease developed in 12 (10.5%) infants, whereas 70 (61.4%) infants showed no manifestations. Cord blood IgE levels in infants with obvious atopic disease was higher when compared to those without (p = 0.024), with 70.97% sensitivity and 46.2% specificity. IgE levels were also significantly different up to 12 months in these groups (p = 0.0001), when the sensitivity was 82.1% and the specificity 54.1%. At this age, the IgE levels were higher in infants with obvious atopy than nonatopic disease in relation to male sex (p = 0.015), black race (p = 0.009), breast-feeding for less than 6 months (p = 0.011) and when the family income was less than three times the minimum wage (about US $300) (p = 0.006). There was no association between IgE levels and family history of atopy. We concluded that immune response for atopy was in a large degree influenced by environmental factors and serum IgE at 12 months was a good marker for identifying infants with risk of atopic disease in early life.en
dc.relation.ispartofJournal Of Investigational Allergology & Clinical Immunologypt_BR
dc.relation.ispartofabbreviationJ Investig Allergol Clin Immunolpt_BR
dc.identifier.citationJournal Of Investigational Allergology & Clinical Immunology. v. 9, n. 6, p. 392-8pt_BR
dc.language.isoengpt_BR
dc.description.volume9pt_BR
dc.description.firstpage392-8pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1018-9068pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/10664935pt_BR
dc.date.available2015-11-27T12:19:46Z-
dc.date.accessioned2015-11-27T12:19:46Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:19:46Z (GMT). No. of bitstreams: 1 pmed_10664935.pdf: 298957 bytes, checksum: 7f209eeabe89563c47b553b719b960f5 (MD5) Previous issue date: nullen
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194467-
dc.identifier.idPubmed10664935pt_BR
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