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Type: Artigo de periódico
Title: Bone Density Among Long-term Users Of Medroxyprogesterone Acetate As A Contraceptive.
Author: Paiva, L C
Pinto-Neto, A M
Faundes, A
Abstract: The bone density (BD) of 72 women using depot-medroxyprogesterone acetate (DMPA) for at least 1 year was compared with that of 64 women who were not users of hormonal contraceptives. The BD of lumbar spine, femoral neck, Ward's triangle, and trochanter was measured by dual energy X-ray absorptiometry (DEXA-LUNAR DPX). Estradiol (E2) concentrations were measured by radioimmunoassay (RIA). The mean age of DMPA users and nonusers was 31.8 and 31.1 years, respectively. Mean E, was 55.7 pg/mL for users and 149.9 pg/mL for controls (p < 0.001). The BD was significantly lower for DMPA users than for controls in all sites (p < 0.01). In addition, young adult T-scores in the lumbar spine were significantly lower among DMPA users than in controls (p < 0.01). Differences were maintained in a subsample of 47 women per group paired by age and body mass index (BMI). Multiple regression analysis showed that older age, lower BMI, and longer amenorrhea were associated with lower BD in the femoral neck, whereas lower BMI and use of DMPA were associated with lower BD in the lumbar spine.
Subject: Absorptiometry, Photon
Bone Density
Contraceptive Agents, Female
Cross-sectional Studies
Medroxyprogesterone Acetate
Progesterone Congeners
Regression Analysis
Time Factors
Comparative Studies
Contraceptive Agents, Female--pharmacodynamics
Contraceptive Agents, Progestin--pharmacodynamics
Contraceptive Agents--pharmacodynamics
Contraceptive Methods--side Effects
Demographic Factors
Developing Countries
Family Planning
Injectables--side Effects
Latin America
Longterm Effects--women
Medroxyprogesterone Acetate--pharmacodynamics
Population Dynamics
Research Methodology
Research Report
Risk Factors--women
Skeletal Effects--women
South America
Time Factors
Citation: Contraception. v. 58, n. 6, p. 351-5, 1998-Dec.
Rights: fechado
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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