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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDistribution Of Hla-drb1 Alleles In A Mixed Population With Insulin-dependent Diabetes Mellitus From The Southeast Of Brazil.pt_BR
dc.contributor.authorMarques, S Bpt_BR
dc.contributor.authorVolpini, Wpt_BR
dc.contributor.authorCaillat-Zucman, Spt_BR
dc.contributor.authorLieber, S Rpt_BR
dc.contributor.authorPavin, E Jpt_BR
dc.contributor.authorPersoli, L Bpt_BR
unicamp.authorS B Marques, Laboratório de Histocompatibilidade do Hemocentro, Universidade Estadual de Campinas, SP, Brasil.pt_BR
unicamp.author.externalW Volpini,pt
unicamp.author.externalS Caillat-Zucman,pt
unicamp.author.externalS R Lieber,pt
unicamp.author.externalE J Pavin,pt
unicamp.author.externalL B Persoli,pt
dc.subjectAdolescentpt_BR
dc.subjectAllelespt_BR
dc.subjectBrazilpt_BR
dc.subjectDiabetes Mellitus, Type 1pt_BR
dc.subjectDisease Susceptibilitypt_BR
dc.subjectElectron Transport Complex Ivpt_BR
dc.subjectEuropean Continental Ancestry Grouppt_BR
dc.subjectFemalept_BR
dc.subjectGene Frequencypt_BR
dc.subjectGenetics, Populationpt_BR
dc.subjectGenome, Fungalpt_BR
dc.subjectGenotypept_BR
dc.subjectHla-dr Antigenspt_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectSaccharomyces Cerevisiaept_BR
dc.description.abstractHLA class II genes are strongly associated with susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). The present study reports the HLA-DRB1 genotyping of 41 IDDM patients and 99 healthy subjects from the Southeast of Brazil (Campinas region). Both groups consisted of an ethnic mixture of Caucasian, African Negro and Amerindian origin. HLA-DRB1*03 and *04 alleles were found at significantly higher frequencies among IDDM patients compared to the controls (DRB1*03: 48.8% vs 18.2%, P < 0.005, RR = 4.27; DRB1*04: 43.9% vs 15.1%, P < 0.008, RR = 4.37) and were associated with a susceptibility to the disease. DRB1*03/*04 heterozygosity conferred a strong IDDM risk (RR = 5.44). In contrast, the HLA-DRB1*11 allele frequency was lower among IDDM patients (7.3% vs 26.3% in controls), but the difference was not significant. These data agree with those described for other populations and allow genetic characterization of IDDM in Brazil.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.date.issued1998-Marpt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 31, n. 3, p. 365-8, 1998-Mar.pt_BR
dc.language.isoengpt_BR
dc.description.volume31pt_BR
dc.description.firstpage365-8pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/9698783pt_BR
dc.date.available2015-11-27T12:19:18Z-
dc.date.accessioned2015-11-27T12:19:18Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:19:18Z (GMT). No. of bitstreams: 1 pmed_9698783.pdf: 23229 bytes, checksum: dea62c6099577864ea230a481f61a290 (MD5) Previous issue date: 1998en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194209-
dc.identifier.idPubmed9698783pt_BR
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