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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleActivation Of The Potato Plant Uncoupling Mitochondrial Protein Inhibits Reactive Oxygen Species Generation By The Respiratory Chain.pt_BR
dc.contributor.authorKowaltowski, A Jpt_BR
dc.contributor.authorCosta, A Dpt_BR
dc.contributor.authorVercesi, A Ept_BR
unicamp.authorA J Kowaltowski, Departamento de Patologia Clinica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brazil.pt_BR
unicamp.author.externalA D Costa,pt
unicamp.author.externalA E Vercesi,pt
dc.subjectAdenosine Triphosphatept_BR
dc.subjectAnimalspt_BR
dc.subjectCalciumpt_BR
dc.subjectCarrier Proteinspt_BR
dc.subjectElectron Transportpt_BR
dc.subjectHydrogen Peroxidept_BR
dc.subjectIon Channelspt_BR
dc.subjectLinoleic Acidpt_BR
dc.subjectMembrane Potentialspt_BR
dc.subjectMembrane Proteinspt_BR
dc.subjectMitochondriapt_BR
dc.subjectMitochondria, Liverpt_BR
dc.subjectMitochondrial Proteinspt_BR
dc.subjectRatspt_BR
dc.subjectReactive Oxygen Speciespt_BR
dc.subjectSerum Albumin, Bovinept_BR
dc.subjectSolanum Tuberosumpt_BR
dc.description.abstractA variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H2O2 generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H2O2 generation. This H2O2 generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O2 by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.en
dc.relation.ispartofFebs Letterspt_BR
dc.relation.ispartofabbreviationFEBS Lett.pt_BR
dc.date.issued1998-Marpt_BR
dc.identifier.citationFebs Letters. v. 425, n. 2, p. 213-6, 1998-Mar.pt_BR
dc.language.isoengpt_BR
dc.description.volume425pt_BR
dc.description.firstpage213-6pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0014-5793pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/9559650pt_BR
dc.date.available2015-11-27T12:19:12Z-
dc.date.accessioned2015-11-27T12:19:12Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:19:12Z (GMT). No. of bitstreams: 1 pmed_9559650.pdf: 94634 bytes, checksum: b443ac3321d717202f3297a5367de68f (MD5) Previous issue date: 1998en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194153-
dc.identifier.idPubmed9559650pt_BR
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