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Type: Artigo de periódico
Title: Activation Of The Potato Plant Uncoupling Mitochondrial Protein Inhibits Reactive Oxygen Species Generation By The Respiratory Chain.
Author: Kowaltowski, A J
Costa, A D
Vercesi, A E
Abstract: A variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H2O2 generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H2O2 generation. This H2O2 generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O2 by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.
Subject: Adenosine Triphosphate
Carrier Proteins
Electron Transport
Hydrogen Peroxide
Ion Channels
Linoleic Acid
Membrane Potentials
Membrane Proteins
Mitochondria, Liver
Mitochondrial Proteins
Reactive Oxygen Species
Serum Albumin, Bovine
Solanum Tuberosum
Citation: Febs Letters. v. 425, n. 2, p. 213-6, 1998-Mar.
Rights: fechado
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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