Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193948
Type: Artigo de periódico
Title: Cross-talk Between The Insulin And Angiotensin Signaling Systems.
Author: Velloso, L A
Folli, F
Sun, X J
White, M F
Saad, M J
Kahn, C R
Abstract: Angiotensin II (AII), acting via its G-protein linked receptor, is an important regulator of cardiac, vascular, and renal function. Following injection of AII into rats, we find that there is also a rapid tyrosine phosphorylation of the major insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) in the heart. This phenomenon appears to involve JAK2 tyrosine kinase, which associates with the AT1 receptor and IRS-1/IRS-2 after AII stimulation. AII-induced phosphorylation leads to binding of phosphatidylinositol 3-kinase (PI 3-kinase) to IRS-1 and IRS-2; however, in contrast to other ligands, AII injection results in an acute inhibition of both basal and insulin-stimulated PI 3-kinase activity. The latter occurs without any reduction in insulin receptor or IRS phosphorylation or in the interaction of the p85 and p110 subunits of PI 3-kinase with each other or with IRS-1/IRS-2. These effects of AII are inhibited by AT1 receptor antagonists. Thus, there is direct cross-talk between insulin and AII signaling pathways at the level of both tyrosine phosphorylation and PI 3-kinase activation. These interactions may play an important role in the association of insulin resistance, hypertension, and cardiovascular disease.
Subject: Angiotensin Ii
Animals
Electrophoresis, Polyacrylamide Gel
Insulin
Insulin Receptor Substrate Proteins
Intracellular Signaling Peptides And Proteins
Janus Kinase 1
Janus Kinase 2
Janus Kinase 3
Male
Phosphatidylinositol 3-kinases
Phosphoproteins
Phosphorylation
Phosphotransferases (alcohol Group Acceptor)
Protein-tyrosine Kinases
Proto-oncogene Proteins
Rats
Rats, Wistar
Signal Transduction
Tyrosine
Citation: Proceedings Of The National Academy Of Sciences Of The United States Of America. v. 93, n. 22, p. 12490-5, 1996-Oct.
Rights: aberto
Address: http://www.ncbi.nlm.nih.gov/pubmed/8901609
Date Issue: 1996
Appears in Collections:Unicamp - Artigos e Outros Documentos

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