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Type: Artigo de periódico
Title: Oxidative Damage Of Mitochondria Induced By Fe(ii)citrate Or T-butyl Hydroperoxide In The Presence Of Ca2+: Effect Of Coenzyme Q Redox State.
Author: Castilho, R F
Kowaltowski, A J
Meinicke, A R
Vercesi, A E
Abstract: The role of coenzyme Q on the process of mitochondrial membrane damage associated with oxidative stress was studied in a suspension of uncoupled mitochondria exposed to Ca2+ in the presence of Fe(II)citrate or t-butyl hydroperoxide. Reduction of coenzyme Q by succinate was shown to inhibit both inner membrane lipid peroxidation and permeabilization induced by Fe(II)citrate. In contrast, the inner membrane permeabilization induced by Ca2+ alone or Ca2+ plus t-butyl hydroperoxide was potentiated by the presence of succinate. These results support our previous proposition that the mitochondrial damage associated with oxidative stress generated by these pro-oxidants in the presence of Ca2+ is mediated by different mechanisms.
Subject: Animals
Antimycin A
Butylated Hydroxytoluene
Ferrous Compounds
Free Radicals
Mitochondria, Liver
Mitochondrial Swelling
Oxidative Stress
Rats, Wistar
Succinic Acid
Thiobarbituric Acid Reactive Substances
Citation: Free Radical Biology & Medicine. v. 18, n. 1, p. 55-9, 1995-Jan.
Rights: fechado
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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