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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleMethodology And Instrumentation For The In Vitro Sinus Node Recovery Time Determination.pt_BR
dc.contributor.authorMarques, J Lpt_BR
dc.contributor.authorBassani, R Apt_BR
dc.contributor.authorBassani, J Wpt_BR
unicamp.authorJ L Marques, Department of Biomedical Engineering, Universidade Estadual de Campinas, Sao Paulo, Brazil.pt_BR
unicamp.author.externalR A Bassani,pt
unicamp.author.externalJ W Bassani,pt
dc.subjectAcetylcholinept_BR
dc.subjectAlgorithmspt_BR
dc.subjectAnimalspt_BR
dc.subjectArrhythmias, Cardiacpt_BR
dc.subjectElectric Stimulationpt_BR
dc.subjectElectrophysiologypt_BR
dc.subjectHeart Ratept_BR
dc.subjectIn Vitro Techniquespt_BR
dc.subjectMalept_BR
dc.subjectNorepinephrinept_BR
dc.subjectRatspt_BR
dc.subjectRats, Inbred Strainspt_BR
dc.subjectSinoatrial Nodept_BR
dc.subjectSoftwarept_BR
dc.description.abstractIn the present work we describe a methodology and a low-cost instrument to determine the sinus node recovery time (SNRT) in the isolated rat right atrium. The instrumentation measures the SNRT using the continuous pacing method and the method of stimulation with premature pulses. When these methods were compared, we observed that the corrected SNRT (CSNRT = SNRT - the mean spontaneous cycle length, MCL) significantly (p less than 0.001) depended on the method used. The effects of norepinephrine (NE) and acetylcholine (ACh) on MCL and CSNRT were also analyzed. Although both neurotransmitters affected MCL (p less than 0.001), only in the presence of ACh a significant (p less than 0.05) correlation between CSNRT and MCL was found. In both methods, the CSNRT values were quite reproducible. The agreement between the data obtained and the predictions of the theoretical models for in vivo SNRT determination suggests that the present methodology may be useful for studies concerning physical and chemical influences on SNRT, as well as for the development of new stimulation tests.en
dc.relation.ispartofJournal Of Pharmacological Methodspt_BR
dc.relation.ispartofabbreviationJ Pharmacol Methodspt_BR
dc.date.issued1990-Aprpt_BR
dc.identifier.citationJournal Of Pharmacological Methods. v. 23, n. 2, p. 117-27, 1990-Apr.pt_BR
dc.language.isoengpt_BR
dc.description.volume23pt_BR
dc.description.firstpage117-27pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0160-5402pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/2332980pt_BR
dc.date.available2015-11-27T12:18:36Z-
dc.date.accessioned2015-11-27T12:18:36Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:18:36Z (GMT). No. of bitstreams: 1 pmed_2332980.pdf: 721520 bytes, checksum: 2e42deaa87246de2f9d5fa90064bc177 (MD5) Previous issue date: 1990en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193839-
dc.identifier.idPubmed2332980pt_BR
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