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Type: Artigo de periódico
Title: Factor V Leiden (fvq 506) Is Common In A Brazilian Population.
Author: Arruda, V R
Annichino-Bizzacchi, J M
Costa, F F
Reitsma, P H
Abstract: Resistance to activated protein C (APC) is the most common risk factor in venous thrombosis. A missense mutation in the factor V gene (factor V Leiden) is the molecular basis for this phenotype. Factor V Leiden was previously found in about 20% of unselected patients with thrombosis but also occurred in 3-5% of healthy Dutch controls. In the present study of Brazilian patients with venous thrombosis we also observed a frequency of 20% for this factor. In addition, in healthy Brazilian controls the frequency of the mutation was 2%. These data suggest that factor V Leiden has a similar distribution worldwide irrespective of the ethnic origin of the population.
Subject: Base Sequence
Drug Resistance
Enzyme Activation
Factor V
Gene Frequency
Molecular Sequence Data
Protein C
Citation: American Journal Of Hematology. v. 49, n. 3, p. 242-3, 1995-Jul.
Rights: fechado
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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