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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleOxidative Damage Of Mitochondria Induced By Fe(ii)citrate Is Potentiated By Ca2+ And Includes Lipid Peroxidation And Alterations In Membrane Proteins.pt_BR
dc.contributor.authorCastilho, R Fpt_BR
dc.contributor.authorMeinicke, A Rpt_BR
dc.contributor.authorAlmeida, A Mpt_BR
dc.contributor.authorHermes-Lima, Mpt_BR
dc.contributor.authorVercesi, A Ept_BR
unicamp.authorR F Castilho, Departamento de Bioquímica, Universidade Estadual de Campinas, SP, Brazil.pt_BR
unicamp.author.externalA R Meinicke,pt
unicamp.author.externalA M Almeida,pt
unicamp.author.externalM Hermes-Lima,pt
unicamp.author.externalA E Vercesi,pt
dc.subjectAnimalspt_BR
dc.subjectCalciumpt_BR
dc.subjectDrug Synergismpt_BR
dc.subjectEgtazic Acidpt_BR
dc.subjectFerrous Compoundspt_BR
dc.subjectIntracellular Membranespt_BR
dc.subjectIronpt_BR
dc.subjectKineticspt_BR
dc.subjectLipid Peroxidationpt_BR
dc.subjectMembrane Potentialspt_BR
dc.subjectMembrane Proteinspt_BR
dc.subjectMitochondria, Liverpt_BR
dc.subjectMitochondrial Swellingpt_BR
dc.subjectOnium Compoundspt_BR
dc.subjectOrganophosphorus Compoundspt_BR
dc.subjectOxygen Consumptionpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectRuthenium Redpt_BR
dc.subjectTime Factorspt_BR
dc.description.abstractIsolated rat liver mitochondria exposed to Fe(II)citrate undergo lipid peroxidation and alterations in membrane proteins. These processes were associated with irreversible decrease in membrane potential and mitochondrial swelling. Lipid peroxidation was evidenced by the production of thiobarbituric acid-reactive substances and also by the reaction of these products with membrane proteins, through the formation of Schiff bases. Alterations in membrane proteins were also characterized by the loss of specific proteins that could be recovered from the mitochondrial supernatant as shown by SDS-polyacrylamide gel electrophoresis. The degree of both lipid peroxidation and alterations in membrane proteins were diminished by EGTA, ruthenium red, or dibucaine. This strongly indicates that Ca2+ potentiates the oxidative damage of mitochondria exposed to Fe(II)citrate.en
dc.relation.ispartofArchives Of Biochemistry And Biophysicspt_BR
dc.relation.ispartofabbreviationArch. Biochem. Biophys.pt_BR
dc.date.issued1994-Janpt_BR
dc.identifier.citationArchives Of Biochemistry And Biophysics. v. 308, n. 1, p. 158-63, 1994-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume308pt_BR
dc.description.firstpage158-63pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0003-9861pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/7508707pt_BR
dc.date.available2015-11-27T12:18:25Z-
dc.date.accessioned2015-11-27T12:18:25Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:18:25Z (GMT). No. of bitstreams: 1 pmed_7508707.pdf: 574421 bytes, checksum: 4aa4e9408ac494b81220362e601fcf1e (MD5) Previous issue date: 1994en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193746-
dc.identifier.idPubmed7508707pt_BR
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