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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.title[detection Of Hemophilia A Gene Carriers In A Brazilian Population].pt_BR
dc.contributor.authorArruda, V Rpt_BR
dc.contributor.authorAnnichino-Bizzacchi, J Mpt_BR
dc.contributor.authorCosta, F Fpt_BR
unicamp.authorV R Arruda, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas-UNICAMP, SP.pt_BR
unicamp.author.externalJ M Annichino-Bizzacchi,pt
unicamp.author.externalF F Costa,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectBase Sequencept_BR
dc.subjectBrazilpt_BR
dc.subjectChildpt_BR
dc.subjectChild, Preschoolpt_BR
dc.subjectDeoxyribonuclease Hindiiipt_BR
dc.subjectFactor Viiipt_BR
dc.subjectFemalept_BR
dc.subjectHemophilia Apt_BR
dc.subjectHeterozygote Detectionpt_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectMolecular Sequence Datapt_BR
dc.subjectPolymorphism, Restriction Fragment Lengthpt_BR
dc.description.abstractThe identification of carriers for the hemophilia A gene was carried out in 20 families of hemophilia A patients. The detection of the carriers was performed on the basis of the study of restriction length fragment polymorphism (RLFPs) for the enzymes BclI and HindIII. The procedures for the determination of RLFPs included the amplification of fragment of the factor VIII gene by the polymerase chain reaction (PCR) followed by digestion with the appropriate enzyme. We studied 84 relatives of the patients with hemophilia A and was possible to detect carriers in 76% of the families. The results presented here indicate that is possible to identify carriers for hemophilia A in most of the families of patients from the Brazilian population employing a limited number of RFLPs.en
dc.relation.ispartofRevista Da Associação Médica Brasileira (1992)pt_BR
dc.relation.ispartofabbreviationRev Assoc Med Braspt_BR
dc.identifier.citationRevista Da Associação Médica Brasileira (1992). v. 39, n. 3, p. 126-30pt_BR
dc.language.isoporpt_BR
dc.description.volume39pt_BR
dc.description.firstpage126-30pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0104-4230pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/7904214pt_BR
dc.date.available2015-11-27T12:18:16Z-
dc.date.accessioned2015-11-27T12:18:16Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:18:16Z (GMT). No. of bitstreams: 0 Previous issue date: nullen
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193679-
dc.identifier.idPubmed7904214pt_BR
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