Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193666
Type: Artigo de periódico
Title: Anti-trypanosoma-cruzi-proteinase Antibodies And Immunoprotection In Experimental Chagas' Disease.
Author: Sakurada, J K
Maury, A
Tamashiro, W M
Araújo, P M
Camargo, I J
Rangel, H A
Abstract: To verify whether anti-Trypanosoma-cruzi-proteinase antibodies are able to play a role in the development of Chagas' disease, CBA/J and C57BL/6 mice were immunized with purified proteinase fractions: antibody production was studied and passive immunization experiments were carried out. No significant differences were observed in the titre, isotype composition and specificity of the antibodies produced by the mouse strains. Immune sera produced in one strain was able to protect mice of both strains, provided that the challenge did not exceed the number of parasites corresponding to 30-fold the LD50. The data presented suggest that anti-proteinase antibodies may play a role in immunoprotection.
Subject: Animals
Antibodies, Protozoan
Chagas Disease
Disease Models, Animal
Endopeptidases
Female
Immunization, Passive
Male
Mice
Mice, Inbred C57bl
Mice, Inbred Cba
Trypanosoma Cruzi
Citation: Research In Immunology. v. 143, n. 2, p. 157-64, 1992-Feb.
Rights: fechado
Address: http://www.ncbi.nlm.nih.gov/pubmed/1574641
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

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